Synthesis, characterization, bactericidal activity, and mechanical properties of hydroxyapatite nano powders impregnated with silver and zinc oxide nanoparticles (Ag-ZnO-Hap)

Bensalem, A.; Kucukosman, Oguz Kaan; Raszkiewicz, James; Topkaya, Ferhat

doi:10.1016/j.ceramint.2021.04.139

Cited by 22 publications

(9 citation statements)

References 26 publications

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“…The nanosized hydroxyapatite embedded with Ag proved to possess an antibacterial effect against the bacteria studied even at a very small ratio of Ag. As in the case of the other studies maintained, once the concentration of Ag is increasing, the inhibition zone is also higher [ 32 ]. The improved properties of Ag beside ZnO were also proved in the study performed by Dumbrava et al [ 33 ], where the antibacterial effect was enhanced after the nanocomposites were obtained.…”

Section: Nanoparticle Typesmentioning

confidence: 53%

“…If the organic composites are preferred for soft tissue restoration, in the case of inorganic materials, the applications usually aim to repair or to improve the hard tissues. Bensalem et al [ 32 ] performed a low-temperature synthesis of a composite based on Ag-ZnO-HAp using very small concentrations of solutions for bone regeneration. The nanosized hydroxyapatite embedded with Ag proved to possess an antibacterial effect against the bacteria studied even at a very small ratio of Ag.…”

Section: Nanoparticle Typesmentioning

confidence: 99%

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Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Nicolae-Maranciuc

Chicea

2022

IJMS

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Silver nanoparticles have been intensively studied over a long period of time because they exhibit antibacterial properties in infection treatments, wound healing, or drug delivery systems. The advantages that silver nanoparticles offer regarding the functionalization confer prolonged stability and make them suitable for biomedical applications. Apart from functionalization, silver nanoparticles exhibit various shapes and sizes depending on the conditions used through their fabrications and depending on their final purpose. This paper presents a review of silver nanoparticles with respect to synthesis procedures, including the polluting green synthesis. Currently, the most commonly used characterization techniques required for nanoparticles investigation in antibacterial treatments are described briefly, since silver nanoparticles possess differences in their structure or morphology.

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Section: Nanoparticle Typesmentioning

confidence: 53%

Section: Nanoparticle Typesmentioning

confidence: 99%

Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Nicolae-Maranciuc

Chicea

2022

IJMS

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“…From these studies, it is clear that the addition of GO and rGO onto collagen scafolds assists in bone tissue engineering and shows good biocompatible aspects. Calcium hydroxyapatite (HAP) is another material used in bone tissue engineering due to its excellent biocompatibility and osteoconductivity [128]. However, on its own, it has low mechanical stability, low wear resistance, and low specifc surface area [129].…”

Section: Graphene-based Materials In Regenerative Bone Tissue Enginee...mentioning

confidence: 99%

“…Calcium hydroxyapatite (HAP) is another material used in bone tissue engineering due to its excellent biocompatibility and osteoconductivity [ 128 ]. However, on its own, it has low mechanical stability, low wear resistance, and low specific surface area [ 129 ].…”

Section: Graphene-based Materials In Regenerative Bone Tissue Enginee...mentioning

confidence: 99%

Graphene-Based Materials in Dental Applications: Antibacterial, Biocompatible, and Bone Regenerative Properties

Williams

Moore

Thomas

et al. 2023

International Journal of Biomaterials

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Graphene-based materials have been shown to have advantageous properties in biomedical and dental applications due to their high mechanical, physiochemical, antibacterial, and stem cell differentiating properties. Although graphene-based materials have displayed appropriate biocompatible properties when used in implant materials for orthopedic applications, little research has been performed to specifically test the biocompatibility of graphene for dental applications. The oral environment, compared to the body, varies greatly and must be considered when evaluating biocompatibility requirements for dental applications. This review will discuss in vitro and in vivo studies that assess graphene’s cytotoxicity, antibacterial properties, and cell differentiation ability to evaluate the overall biocompatibility of graphene-based materials for dental applications. Particle shape, size, and concentration were found to be major factors that affected overall biocompatibility of graphene.

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“…Nanoapatites prepared by the co-precipitation of metal ions with Ca 2+ can target bacterial cells; they penetrate and damage the cell membrane, promote protein alkylation, and cause oxidative stress, thus resulting in genetic material damage and death [ 31 ]. Adding appropriate amounts of metal ions (e.g., Cu 2+ , Mg 2+ , Zn 2+ , Ag + , Sr 2+ , Li + , and Si 4+ ) to the HA lattice does not affect the structural configuration and biocompatibility and can effectively change the lattice, crystallinity, solubility, bacteriostatic, and angiogenesis of nanoapatites [ 32 , 33 , 34 , 35 , 36 , 37 ]. Cu 2+ , Mg 2+ , and Zn 2+ metal ions with nearly the same anion radius were investigated as targets for the hydrothermal synthesis of doped nanoapatites.…”

Section: Introductionmentioning

confidence: 99%

Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

et al. 2022

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The objective of this study was to prepare hydroxyapatite (HA) with potential antibacterial activity against gram-negative and gram-positive bacteria by incorporating different atomic ratios of Cu2+ (0.1–1.0%), Mg2+ (1.0–7.0%), and Zn2+ (1.0–7.0%) to theoretically replace Ca2+ ions during the hydrothermal synthesis of grown precipitated HA nanorods. This study highlights the role of comparing different metal ions on synthetic nanoapatite in regulating the antibacterial properties and toxicity. The comparisons between infrared spectra and between diffractograms have confirmed that metal ions do not affect the formation of HA phases. The results show that after doped Cu2+, Mg2+, and Zn2+ ions replace Ca2+, the ionic radius is almost the same, but significantly smaller than that of the original Ca2+ ions, and the substitution effect causes the lattice distance to change, resulting in crystal structure distortion and reducing crystallinity. The reduction in the length of the nanopatites after the incorporation of Cu2+, Mg2+, and Zn2+ ions confirmed that the metal ions were mainly substituted during the growth of the rod-shape nanoapatite Ca2+ distributed along the longitudinal site. The antibacterial results show that nanoapatite containing Cu2+ (0.1%), Mg2+ (3%), and Zn2+ (5–7%) has obvious and higher antibacterial activity against gram-positive bacteria Staphylococcus aureus within 2 days. The antibacterial effect against the gram-negative bacillus Escherichia coli is not as pronounced as against Staphylococcus aureus. The antibacterial effect of Cu2+ substituted Ca2+ with an atomic ratio of 0.1~1.0% is even better than that of Mg2+- and Zn2+- doped with 1~7% groups. In terms of cytotoxicity, nanoapatites with Cu2+ (~0.2%) exhibit cytotoxicity, whereas Mg2+- (1–5%) and Zn2+- (~1%) doped nanoapatites are biocompatible at low concentrations but become cytotoxic as ionic concentration increases. The results show that the hydrothermally synthesized nanoapatite combined with Cu2+ (0.2%), Mg2+ (3%), and Zn2+ (3%) exhibits low toxicity and high antibacterial activity, which provides a good prospect for bypassing antibiotics for future biomedical applications.

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Synthesis, characterization, bactericidal activity, and mechanical properties of hydroxyapatite nano powders impregnated with silver and zinc oxide nanoparticles (Ag-ZnO-Hap)

Cited by 22 publications

References 26 publications

Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Graphene-Based Materials in Dental Applications: Antibacterial, Biocompatible, and Bone Regenerative Properties

Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

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