Synthesis, Characterization, Novel Interaction of DNA, Antioxidant and Antimicrobial Studies of New Water Soluble Metallophthalocyanines Posture Eight Hydroxyphenyl Moiety via 1,3,4-oxadiazole Bridge

Abstract

in Wiley Online Library (wileyonlinelibrary.com).The new peripheral 2(3),9(10),16(17),23(24)-tetra-5-[4,4′-diphenol]-phenyl-[1,3,4]-oxadiazole substituted metallophthalocyanine (MPc) complexes has been well designed and executed. Due to high conjugation and excellent solubility in water makes them potential use in DNA binding and cleavage studies. Fourier transform infrared spectroscopy, nuclear magnetic resonance, electron spin ionization mass spectra data, and elemental analysis confirmed the well-defined saddle-like distorted structures for these substituted MPc complexes. The successful synthesis of these novel water soluble MPc moieties were employed as an effective DNA binding with calf thymus DNA was monitored using ultravioletÀvisible spectral titrations and cleavage pBR322 DNA conceded in the absence of reductant by agarose gel electrophoresis method. The results indicate that all these water soluble complexes significantly show excellent binding and modest cleavage sensitivity activity. It is noteworthy that 6 and 7 exhibit potential antimicrobial and appreciable antioxidant activity with other water soluble phthalocyanines.

Charge‐Transfer Complex of p‐Aminodiphenylamine with Maleic Anhydride: Spectroscopic, Electrochemical, and Physical Properties

“…The thermogramss how am ass loss below 100 8Cdue to the loss of moisture from the samples with an exothermic decomposition (about 0.33 %w eight loss). [41] The decomposition temperature of CTC and PADPA were determined as 263 and 233 8C, respectively.T he MA component of the MA-PADPAc omplex hasadecompositiont emperatureo f1 40 8C. [42] In ac omparison of the weight losses, MA-PADPAh as higher thermals tability( 82.70 %) than PADPA (37.7 %) at 300 8C( Table 2).…”