in Wiley Online Library (wileyonlinelibrary.com).The new peripheral 2(3),9(10),16(17),23(24)-tetra-5-[4,4′-diphenol]-phenyl-[1,3,4]-oxadiazole substituted metallophthalocyanine (MPc) complexes has been well designed and executed. Due to high conjugation and excellent solubility in water makes them potential use in DNA binding and cleavage studies. Fourier transform infrared spectroscopy, nuclear magnetic resonance, electron spin ionization mass spectra data, and elemental analysis confirmed the well-defined saddle-like distorted structures for these substituted MPc complexes. The successful synthesis of these novel water soluble MPc moieties were employed as an effective DNA binding with calf thymus DNA was monitored using ultravioletÀvisible spectral titrations and cleavage pBR322 DNA conceded in the absence of reductant by agarose gel electrophoresis method. The results indicate that all these water soluble complexes significantly show excellent binding and modest cleavage sensitivity activity. It is noteworthy that 6 and 7 exhibit potential antimicrobial and appreciable antioxidant activity with other water soluble phthalocyanines.

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A series of new 3-(2, 4-dichlorophenyl)-1-(2-(substituted phenoxy) acetyl)-1H-pyrazole-4-carbaldehyde were synthesized from substituted simple phenols. Substituted simple phenols were refluxed with ethylchloroacetate in presence of anhydrous potassium carbonate to yield substituted ethyl phenoxy acetate. Further substituted ethyl phenoxy acetate on treatment with hydrazine hydrate in ethanol yielded substituted 2-phenoxyacetohydrazide in turn on refluxing with 2,4-dichloro acetophenones yielded N'-(1-(2,4-dichlorophenyl)ethylidene)-2-(substituted phenoxy) acetohydrazides which on further treatment with DMF and POCl3 undergo Vilsmer - Haack reaction to yield the title compounds i.e. 3-(2,4-dichlorophenyl)-1-(2 (substituted phenoxy)acetyl)-1H-pyrazole-4-carbaldehyde (4a-j). The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1H NMR, mass spectral data and elemental analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram +ve and gram -ve bacterial strains such as Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and fungi strains Candida albicans and Aspergillus niger. Antimicrobial activity was carried out by cup-plate method; zone of inhibition shown by the compounds against selected microorganisms was measured by using antibiotic zone reader. The minimum inhibitory concentration was carried out for the promising compounds were determined by serial dilution method. The chloro and bromo possessing moiety have shown enhanced biological activity stimulated to synthesize more efficient drug containing more electronegative moiety against pathogenic microorganisms