Synthesis, characterization of ruthenium (III) macrocyclic complexes of 1,4,8,11-tetraazacyclotetradecane(cyclam) and in vitro assessment of anti-cancer activity
“…A Ru(III) complex with 1,4,8,11-tetraazacyclotetradecane exhibited an antiproliferative effect against SiHa cells, with an IC 50 of 48 μM after 48 h of exposure [ 77 ]. Cell morphology changes were observed, such as nuclear fragmentation.…”
Section: Novel Metal Complexes In Cancer Therapymentioning
Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor activity. Coordination compounds of transition metals such as platinum (Pt), ruthenium (Ru) and gold (Au) have proven their effectiveness as diagnostic and/or antiproliferative agents. In recent years, experimental work on the potential applications of elements including lanthanum (La) and the post-transition metal gallium (Ga) in the field of oncology has been gaining traction. The authors of the present review article aim to help the reader “catch up” with some of the latest developments in the vast subject of coordination compounds in oncology. Herewith is offered a review of the published scientific literature on anticancer coordination compounds of Pt, Ru, Au, Ga and La that has been released over the past three years with the hope readers find the following article informative and helpful.
“…A Ru(III) complex with 1,4,8,11-tetraazacyclotetradecane exhibited an antiproliferative effect against SiHa cells, with an IC 50 of 48 μM after 48 h of exposure [ 77 ]. Cell morphology changes were observed, such as nuclear fragmentation.…”
Section: Novel Metal Complexes In Cancer Therapymentioning
Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor activity. Coordination compounds of transition metals such as platinum (Pt), ruthenium (Ru) and gold (Au) have proven their effectiveness as diagnostic and/or antiproliferative agents. In recent years, experimental work on the potential applications of elements including lanthanum (La) and the post-transition metal gallium (Ga) in the field of oncology has been gaining traction. The authors of the present review article aim to help the reader “catch up” with some of the latest developments in the vast subject of coordination compounds in oncology. Herewith is offered a review of the published scientific literature on anticancer coordination compounds of Pt, Ru, Au, Ga and La that has been released over the past three years with the hope readers find the following article informative and helpful.
“…Therefore, researchers are seeking better ways to eliminate cancer cells, with less side effects. Some researchers are working on the use of various macrocyclic ligands for cancer therapy, making ruthenium an ideal choice over other transition metals due to its special chemical properties[ 4 ]. However, what plagues most cancer treatments is the presence of a small number of cancer stem cells (CSCs) in tumor tissues[ 5 , 6 ], which have the potential for self-renewal, unlimited proliferative capacity, and multidirectional differentiation[ 5 , 7 ].…”
Cancer stem cells (CSCs) are a small proportion of the cells that exist in cancer tissues. They are considered to be the culprit of tumor genesis, development, drug resistance, metastasis and recurrence because of their self-renewal, proliferation, and differentiation potential. The elimination of CSCs is thus the key to cure cancer, and targeting CSCs provides a new method for tumor treatment. Due to the advantages of controlled sustained release, targeting and high biocompatibility, a variety of nanomaterials are used in the diagnosis and treatments targeting CSCs and promote the recognition and removal of tumor cells and CSCs. This article mainly reviews the research progress of nanotechnology in sorting CSCs and nanodrug delivery systems targeting CSCs. Furthermore, we identify the problems and future research directions of nanotechnology in CSC therapy. We hope that this review will provide guidance for the design of nanotechnology as a drug carrier so that it can be used in clinic for cancer therapy as soon as possible.
“…With increasing concentration of drug the viability of cells, were decreased. Authors demonstrated that complex exhibited significant anticancer attribute in the pathogenesis of cervical cancer [ 37 ]. Fig.…”
Role of synthetic coordination chemistry in pharmaceutical science is expeditiously increased due to its sundry relevances in this field. The present review endows the synthesized macrocyclic complexes of transition metal ions containing isatin and its derivatives as ligand precursors, their characterization and their copious pharmaceutical applications. Isatin (1
H
-Indole-2,3-dione) is a protean compound (presence of lactam and keto moiety permits to change its molecular framework) that can be obtained from marine animals, plants, and is also found in mammalian tissues and in human fluids as a metabolite of amino acids. It can be used for the synthesis of miscellaneous organic and inorganic complexes and for designing of drugs since it has remarkable utility in pharmaceutical industry due to its wide range of biological and pharmacological activities, for instance anti-microbial, anti-HIV, anti-tubercular, anti-cancer, anti-viral, anti-oxidant, anti-inflammatory, anti-angiogenic, analgesic activity, anti-Parkinson’s disease, anti-convulsant etc. This review provides extensive information about the latest methods for the synthesis of isatin or its substituted derivatives based macrocyclic complexes of transition metals and their plentiful applications in medicinal chemistry.
Graphical Abstract
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