Synthesis, crystal structures, and biological activity of zinc(II) complexes derived from 2-amino-1,3,4-thiadiazole derivatives

Abstract

Two new similar zinc(II) complexes, [ZnCl 2 L1 2 ] and [ZnCl 2 L2 2 ] derived from the 2-amino-1,3,4-thiadiazole derivatives, were prepared and structurally characterized by X-ray diffraction. The Zn atom in each complex has a tetrahedral coordination and is coordinated by two N atoms of the ligands and two Cl atoms. The urease inhibitory activities of the complexes and the ligands were evaluated.

2-Amino-1,3,4-Thiadiazole Derivatives as Potential Anti-Helicobacter Pylori Agents – At a Glance

“…Studies of inhibitory activities performed for ligands 21 and 22, as well as metal complexes 23 and 24 at a concentration of 100 μg/mL showed that, compared to acetohydroxamic acid as a reference (92.34% inhibition), ligand 21 is a weak urease-inhibitor (4.30% inhibition), whereas ligand 22 did not inhibit urease at all. Increased activity was observed for complexes 23 and 24, with inhibition values of 14.31% and 17.8%, respectively, suggesting that metal complexes may enhance biological activity and this strategy can be used for the development of new enzyme inhibitors[45].…”