Synthesis, DNA binding, photo-induced DNA cleavage and cell cytotoxicity studies of a family of light rare earth complexes

Chen, Gong-Jun; Qiao, Xin; Gao, Chunyan; Xu, Guang-Jun; Zhi-ling, Wang; Tian, Jin‐Lei; Xu, Jing‐Yuan; Gu, Wen; Liu, Xin; Shi, Yan

doi:10.1016/j.jinorgbio.2011.12.009

Cited by 38 publications

(10 citation statements)

References 57 publications

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“…The working electrode was platinum disk, a separate pt single sheet electrode was used as counter electrode and Ag/AgCl electrode saturated with KCl used as reference electrode. KNO 3 and tris buffer was used as supporting electrolyte. The Cyclic voltammogram of the complex were recorded in tris buffer (pH= 7.2) at 100 mV/s.…”

Section: Experimental a Materials And Methodsmentioning

confidence: 99%

“…Many coordination compounds are able to bind DNA as structural probes[1], DNA foot printing [2], DNA cleaving agents [3][4] and as potential anticancer drugs [5][6]. It is generally believed that many anticancer, antiviral, and antiseptic agents take action through binding DNA [4,[7][8], since the interaction between small molecules and DNA can often cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Tak¹

2017

IJRASET

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Novel complexes of copper (II), cobalt (II) and nickel (II) with sulphapyridine and aminothiazole were synthesized and characterized using spectral and analytical techniques. The interaction of cobalt (II) complexes with herring sperm DNA has been performed using absorption titration, viscometric measurements and cyclic voltammetry. The protective activity of metal complexes has been carried out using arose gel electrophoresis. The results indicate that cobalt (II) complex bind to DNA via electrostatic or groove binding with binding constant K b = 4.5 x 10 4 M -1. The antioxidant activity for cobalt (II) complex was also checked. Keywords: hypochromism, peak potential and binding constant. I. INTRODUCTIONThe binding of metal complexes to DNA has been extensively studied over the past decade. Many coordination compounds are able to bind DNA as structural probes[1], DNA foot printing [2], DNA cleaving agents [3][4] and as potential anticancer drugs [5][6]. It is generally believed that many anticancer, antiviral, and antiseptic agents take action through binding DNA [4,[7][8], since the interaction between small molecules and DNA can often cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death [9][10][11]. Many studies indicate that transition metal complexes can bind to DNA via both covalent (replacement of labile coordinating ligand by nitrogen base of DNA (i.e. adenine, Cytosine, guanine, thymine) and or non covalent interaction (intercalation, electrostatic or groove binding) [12]. Many important applications of these complexes require that they can bind via intercalative mode or groove binding [13]. Therefore interaction of complexes especially with planar aromatic heterocyclic ligands, which can insert into the base pairs of DNA duplex has attracted considerable attention [14][15][16]. is an essential element widely distributed in biological system [6,[17][18]. Numerous cobalt complexes has been studied as hydrolytic agent for DNA cleavage [19-20], antitumor, antproli-ferative[21-23], antimicrobial[24-26] and antifungal [21,27], antiviral [28,29], antioxidant [12 ,30] and ant inflammatory activity [30]. They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33]. Ligands having nitrogen donors received considerable attention because of their mixed hard-soft donor character, versatile coordination behavior [34][35] and for their biological activity (i.e., toxicity against bacterial growth [36], anticancer [37] and other biochemical properties [38]). The coordination geometry and nature of donor atoms play key roles in determining the binding extent of complexes to DNA. The importance of central metal ion at the core of the structure is noteworthy [39,40]. Many DNA heterocyclic compounds such as benzothiazole and benzopyra zine derivatives have been evaluated and f...

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Section: Experimental a Materials And Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Tak¹

2017

IJRASET

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“…In this context, organometallic compounds, defined as metal complexes containing at least one direct covalent metal-carbon bond including those of group 3, have recently been highlighted as good anticancer candidates for their significant biological activity [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes

et al. 2017

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The quest for alternative drugs with respect to the well-known cis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes, evaluated using liposomes as bio-membrane mimetic model systems, seems to be relevant. The biological activity of these compounds, particularly those based on yttrium, already effective at low concentrations on both cancer cell lines, should be taken into account with regard to new therapeutic approaches in anticancer therapy.

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“…Among various metal complexes, La (III) complexes have been intensively investigated due to their more physiological activities and lower toxicities after coordination with ligand. People have paid great interest to synthesis, DNA interaction, and anticancer activity of La (III) complexes in recent years [ 4 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine

Wang

Huang

Zhang

et al. 2014

Bioinorganic Chemistry and Applications

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A novel La (III) complex, [LaL(H2O)3]NO3 ·3H2O, with Schiff base ligand L derived from kaempferol and diethylenetriamine, has been synthesized and characterized by elemental analysis, IR, UV-visible, 1H NMR, thermogravimetric analysis, and molar conductance measurements. The fluorescence spectra, circular dichroism spectra, and viscosity measurements and gel electrophoresis experiments indicated that the ligand L and La (III) complex could bind to CT-DNA presumably via intercalative mode and the La (III) complex showed a stronger ability to bind and cleave DNA than the ligand L alone. The binding constants (K b) were evaluated from fluorescence data and the values ranged from 0.454 to 0.659 × 105 L mol−1 and 1.71 to 17.3 × 105 L mol−1 for the ligand L and La (III) complex, respectively, in the temperature range of 298–310 K. It was also found that the fluorescence quenching mechanism of EB-DNA by ligand L and La (III) complex was a static quenching process. In comparison to free ligand L, La (III) complex exhibited enhanced cytotoxic activities against tested tumor cell lines HL-60 and HepG-2, which may correlate with the enhanced DNA binding and cleaving abilities of the La (III) complex.

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Synthesis, DNA binding, photo-induced DNA cleavage and cell cytotoxicity studies of a family of light rare earth complexes

Cited by 38 publications

References 57 publications

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes

Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine

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