Synthesis of 1,3,4-Oxadiazole Derivatives from Ethyl-2-Piperidone-3-Carboxylate

Sheat, Mohammed A.; Mohammed, O. I.

doi:10.33899/edusj.2012.58997

Cited by 2 publications

(2 citation statements)

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“…1,3,4-Oxadiazoles have also prepared from succinic anhydride and some hydrazides using POCl 3 for cyclization [10]. In 2012 Sheet and Mohammed [11] have succeeded in synthesizing 1,3,4-oxadiazoles from oxidation of hydrazones using PbO 2 . Some thiazole compounds were also found to have medical application [12,13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some thiazole and phthalazine compounds from schiff bases

Al-Ajely¹,

Ali²

2019

Act Scie Medic

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It was known that heterocyclic compounds containing S and N have considerable importance which withdraw researchers attention due to their wide medical and biological applications. In the present investigation we have synthesized some oxadiazole derivatives (A 9-15 ), phthalazine derivatives (A 33-38 ) and Benzo thiazole-2-yl arylthiazol-4-one (A 17-24 ), thiazoles (A 39-41 ) from schiff base precursors. The thiazole compounds were cyclized using acetic anhydride, thioglycolic acid while phthalazines were cyclized using amylalcohol in HCl. The synthesized compounds were studied by IR,1HNMR spectral methods. ExperimentalPhenyl hydrazide (0.01mol.) or 3-Nitrophenyl hydrazide was dissolved in 25 ml of absolute ethanol. Aldehyde or its derivatives was then added. The reaction mixture was refluxed for 2 hours, cooled,stand for 3 hour at r.t. The p.p.t was filtered off and crystallized from ethanol, Physical and IR spectral data were shown in Tables 1,2.Synthesis of (substituted phenyl, substituted benzoyl hydrazonel(A 2-8

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Section: Introductionmentioning

confidence: 99%

Synthesis of some thiazole and phthalazine compounds from schiff bases

Al-Ajely¹,

Ali²

2019

Act Scie Medic

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“…Amide had been reported to posses antibactrial activity (2) substituted amide are acting as inhibitors of HIV proteans (3) , hypertension as analgesic (4) . Amide linkages are not only the key chemical connection of proteins but they are also the basis for some of the most varsatik and widely used synthetic polymer (5) , on the other hand ethers compounds showed bio logical activity such as amide which are used as antipyretic agent (6) , anti inflammatory (7) , herbcidic…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some new 2-(4-Aryliminophenoxy)N-Arylacetamide Via p-hydroxy benzaldehyde.

Journal¹

2014

Baghdad Sci.J

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Chloroacetamide derivatives (2a-g) have been prepared through reaction of chloroacetyl chloride(1) (which prepared by the reaction of chloroacetic acid with thionyl chloride) with primary aromatic amines and sulfa compounds to afford compounds (2a-g) which then reacted with p-hydroxy benzaldehyde via Williamson reaction to obtaine the new compounds 2-(4-formyl phenoxy)-N-aryl acetamide (3a-g). Finally , compounds (3a-g) will be use as a good synthon to prepare the Schiff bases represented by compounds 2-(4-aryliminophenoxy)-N-arylacetamide (4a-g). through , reaction with some primary aromatic amine. All the prepared compounds were investigated by the available physical and spectroscopic methods.

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Synthesis of 1,3,4-Oxadiazole Derivatives from Ethyl-2-Piperidone-3-Carboxylate

Cited by 2 publications

References 10 publications

Synthesis of some thiazole and phthalazine compounds from schiff bases

Synthesis of some thiazole and phthalazine compounds from schiff bases

Synthesis of Some new 2-(4-Aryliminophenoxy)N-Arylacetamide Via p-hydroxy benzaldehyde.

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