2011
DOI: 10.1080/00397911.2010.499488
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Synthesis of 1,4-Dihydropyridine Derivatives Under Solvent-Free and Grinding Conditions

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Cited by 18 publications
(7 citation statements)
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“…Another method for the synthesis of 6-amino-5-cyano-1,4dihydropyridine derivatives has been developed by the one-pot reaction of ethyl acetoacetate, [(2-aryl)methylene]malononitriles, and ammonium acetate at room temperature with grinding. 206 Under microwave irradiation, the one-pot multicomponent condensation reaction of three molar aromatic aldehydes 249 with two molar cyclic ketones with free a,a9-methylene ethylene positions such as cyclopentanone or cyclohexanone 250 in the presence of ammonium acetate 129 and acetic acid afforded dicyclocalkenopyridines 251 in good yields. In similar reaction conditions, 1-tetralone, which has only one a-methylene position, results in 10-aryl-2,3:5,6-dibenzoacridines (Scheme 70).…”
Section: -Arylidene-13-indanediones and (E)-2-oxoindolino-3-ylidene A...mentioning
confidence: 99%
“…Another method for the synthesis of 6-amino-5-cyano-1,4dihydropyridine derivatives has been developed by the one-pot reaction of ethyl acetoacetate, [(2-aryl)methylene]malononitriles, and ammonium acetate at room temperature with grinding. 206 Under microwave irradiation, the one-pot multicomponent condensation reaction of three molar aromatic aldehydes 249 with two molar cyclic ketones with free a,a9-methylene ethylene positions such as cyclopentanone or cyclohexanone 250 in the presence of ammonium acetate 129 and acetic acid afforded dicyclocalkenopyridines 251 in good yields. In similar reaction conditions, 1-tetralone, which has only one a-methylene position, results in 10-aryl-2,3:5,6-dibenzoacridines (Scheme 70).…”
Section: -Arylidene-13-indanediones and (E)-2-oxoindolino-3-ylidene A...mentioning
confidence: 99%
“…35 In another example, the (2-aryl)methylene malononitriles 50 which were prepared from aldehydes and malonitrile have been successfully employed to react with ethyl acetoacetate and ammonia acetate to provide 1,4-DHPs 51 by grinding under solvent-free conditions (Scheme 22). 36 Safari et al developed a new three-component synthesis of NH-free 1,4-DHPs of type 53 using chalcones 52, ethyl acetoacetate and ammonia. Excellent yields of products were obtained in refluxing water with the catalysis of cellulose sulfuric acid (Scheme 23).…”
Section: Multicomponent Synthesis Of 14-dhps Using Ammonia As Amino S...mentioning
confidence: 99%
“…The 5‐amino‐3‐(arylamino)‐1 H ‐pyrazole‐4‐carboxamides 1a,b (Hassan, 2017a; Khatab et al, 2019), 2‐(arylidene)malononitriles (Hafez et al, 2013; Wang et al, 2005; Zonouz & Moghani, 2011), and 3‐(dimethylamino)‐1‐aryl‐prop‐2‐en‐1‐ones (Hassan et al, 2018, 2017b) were prepared as reported in the literature.…”
Section: Methodsmentioning
confidence: 99%