Synthesis of 1,8-Dioxo-octahydroxanthenes and 1,8-Dioxo-decahydroacridines Using an Efficient Cellulose-HClO4 Heterogeneous Catalyst Under Solvent-free Conditions: A Green Protocol

Preparation of Core/Shell Fe3O4@SiO2 ⋅ DIL as a Magnetically Separable Catalyst for the Synthesis of 1, 8‐Dioxodecahydroacridine

“…[13] Besides, the acridine motif has been widely used in chemosensors, dyes, fluorescent probes and as ligands in metal-promoted catalysis. [14] The most straightforward synthesis of 1,8-dioxodecahydroacridines involve the three-component condensation of dimedone, aldehydes, and different anilines or ammonium acetate using different catalysts such as Silica-Bonded S-Sulfonic Acid, [15] FeCl 3 -SiO 2 , [16] Acidic Ionic Liquids, [17] Zn-(OAC) 2 .2H 2 O, [18] Amberlyst-15, [19] Brønsted acidic imidazolium salts, [20] Cellulose-HClO 4 , [21] p-dodecylbenezenesulfonic acid, [22] Ceric ammonium nitrate (CAN), [23] β-Cyclodextrin Monosulphonic Acid [24] and Proline. [25] Although these methods are effective, some of them suffer from one or more drawbacks such as long reaction times, use of large quantities of hazardous solvents, nonrecyclable catalysts, excessive use of reagents, unsatisfactory yields, and tedious conditions.…”

Preparation of core/shell Fe3O4@SiO2 .DIL as a magnetically heterogeneous catalyst for the synthesis of 1, 8‐dioxodecahydroacridine

“…Besides, the acridine motif has been widely used in chemosensors, dyes, uorescent probes and as ligands in metal-promoted catalysis [14]. The most straightforward synthesis of 1,8dioxodecahydroacridines involve the three-component condensation of dimedone, aldehydes, and different anilines or ammonium acetate using different catalysts such as Silica-Bonded S-Sulfonic Acid [15], FeCl 3 -SiO 2 [16], Acidic Ionic Liquids [17], Zn(OAC) 2 .2H 2 O [18], Amberlyst-15 [19], Brønsted acidic imidazolium salts [20], Cellulose-HClO 4 [21], p-dodecylbenezenesulfonic acid [22], Ceric ammonium nitrate (CAN) [23], β-Cyclodextrin Monosulphonic Acid [24] and Proline [25] .…”

Regioselective Synthesis of 3, 5‐Disubstituted Isoxazole Catalyzed by Cu2O−ZnO Nanocomposite

“…[1] Isoxazole is a five-membered heterocyclic scaffold commonly encountered in many natural products and drug molecules. [2] Derivatives of isoxazole exhibit a diverse range of biological and pharmacological activities such as antithrombotic, [3] antibacterial, [4] antagonist, [5] antiviral, [6,7] antitumor, [8] anti-HIV, [9] herbicidal, [10] insecticidal [11] and fungicidal. [12] Isoxazole core has been present in drugs such as sulfamethoxazole [13] contains antibiotic properties, muscimol [14] used as a selective GABAA agonist, ibotenic acid [15] that acts as a neurotoxin, parecoxib [16] shows COX-2 inhibitory properties, and leflunomide [17] behaves as an immunosuppressant agent (Figure 1).…”