Synthesis of 2,3-dihydroquinazolin-4(1H)-ones via one-pot three-component reaction catalyzed by l-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate (supported on silica gel) as novel and recoverable catalyst

Sulfamic acid immobilized on amino‐functionalized magnetic nanoparticles: A new and active magnetically recoverable catalyst for the synthesis of N‐heterocyclic compounds

“…2,3‐Dihydroquinazolin‐4(1 H )‐one‐based compounds continue to attract significant attention in biosynthesis because of their valuable pharmacological and biological activities . They have a vast range of pharmacological and biological activities, such as antitumour, anticancer, analgesic, diuretic and herbicidal activities . The general method applicable for the preparation of 2,3‐dihydroquinazolin‐4(1 H )‐ones is the condensation reaction of 2‐aminobenzamide with aldehydes or ketones in the presence of acidic catalysts .…”

Sulfuric acid heterogenized on magnetic Fe3O4 nanoparticles: A new and efficient magnetically reusable catalyst for condensation reactions

“…[14] Besides, 2, 3-dihydroquinazoline-4(1H)-one derivatives can act as key structural motifs to design the new category of highly valuable synthetic drug candidates owing to their important pharmacological properties. [15,16] Recent literature studies clearly shown that a variety of molecules containing 2, 3-dihydroquinazoline-4(1H)-one structural units exhibit a series of significant biological activities such as antitumor, anticancer, antibiotic, antibacterial, antidefibrillatory, antipyretic, and anticonvulsant [17][18][19] The condensation of aryl, alkyl and hetroaryl aldehydes or ketones with anthranil amide in the presence of acidic catalysts is a well-known approach for the synthesis of 2, 3-dihydroquinazoline-4(1H)-ones. [20] In recent times, a variety of catalysts and promoter or reagents for the synthesis of these compounds have been reported in the literature.…”

Magnetic Fe3O4 nanoparticles supported imine/Thiophene‐nickel (II) complex: A new and highly active heterogeneous catalyst for the synthesis of polyhydroquinolines and 2, 3‐dihydroquinazoline‐4(1H)‐ones

“…[17][18][19][20][21] 2, 3-dihydroquinazoline-4(1H)-one and polyhydroquinoline structural motifs have been known to possess diverse biological activities such as antitumor, anticancer, antibiotic, antidiabetic, antibacterial, antidefibrillatory, antipyretic, and anticonvulsant agents. [22][23][24][25][26][27][28][29][30] Polyhydroquinolines also are well-known drugs for the treatment of cardiovascular and Alzheimer's diseases. [31,32] Furthermore, polyhydroquinoline derivatives are well-known as Ca 2+ channel blockers and drugs of NADH co-enzymes.…”