Synthesis of 5-aryl-6-cinnamoyl-7-methyl-flavanones as novel antioxidants and antihyperlipidemics

Sharma, Anindra; Anand, Namrata; Sharma, Rahul; Chaturvedi, U.S.; Khanna, Ashok; Bhatia, Gitika; Tripathi, Rama Pati

doi:10.3109/14756366.2011.585134

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Water was added to the cooled mixture and the organic layer was extracted with EtOAc, dried using MgSO 4 , filtered and evaporated under reduced pressure. The residual yellow oil was purified using silica gel CC to afford substituted flavanone [12]. …”

Section: General Procedures For the Preparation Of Flavanonementioning

confidence: 99%

Antimicrobial Activities of Some Synthetic Flavonoids

Ibrahim¹,

Ahmed²

2014

IOSRJAC

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Section: General Procedures For the Preparation Of Flavanonementioning

confidence: 99%

Antimicrobial Activities of Some Synthetic Flavonoids

Ibrahim¹,

Ahmed²

2014

IOSRJAC

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Chalcones: Versatile intermediates in heterocyclic synthesis

Nayak

Gaonkar

Sabu

2023

Journal of Heterocyclic Chem

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Chalcones are a fascinating and well‐studied group of organic molecules. Synthesis of chalcones has been one of the essential areas of organic synthesis over the last few decades because of their immense therapeutic and excellent photophysical properties. Furthermore, these chalcone derivatives can be utilized to make a variety of heterocyclic compounds, especially five‐ and six‐membered heterocycles. Heterocyclic compounds have a long history in chemistry, primarily in pharmaceuticals. However, synthesizing some specific heterocyclic molecules remains challenging and requires multistep processes with few possible intermediates. Chalcones can be considered as one of the most useful, readily available intermediates in heterocyclic synthesis. Herein, the synthesis of various potential heterocyclic compounds using chalcones as an intermediate is elaborated. This review shows the untapped potential of chalcones in organic synthesis. Also, it will assist the chemist in designing new heterocycles by adopting these strategies.

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Synthesis and Biological Evaluation of Flavonoids as Antiacetyl- cholinesterase Agent

Ibrahim

Ahmad

2014

Jurnal Teknologi

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A series of chalcones, a flavone and one flavanone were synthesized and elucidated structurally by IR and 1H NMR spectroscopies. The synthetic compounds were then screened for acetylcholinesterase inhibitory activity using thin layer chromatography (TLC) and microplate assays. In the TLC assay, only 2′-hydroxy-4-methoxychalcone and 2′-hydroxy-4′-O-prenyl-2,6-dichlorochalcone were found to show moderate and weak activity respectively against acetylcholinesterase (AchE) at 0.1 mM concentration compared to the control galanthamine. 4′-Hydroxy-2,6-dichlorochalcone, 2′-hydroxy-4-nitrochalcone, 2′-hydroxy-4-(dimethyl)aminochalcone and 2′-hydroxy-4-methoxychalcone showed moderate AchE inhibitory activity with percentage inhibition of 54.24, 46.14 and 49.32 % respectively in the microplate assay.

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Synthesis of 5-aryl-6-cinnamoyl-7-methyl-flavanones as novel antioxidants and antihyperlipidemics

Cited by 3 publications

References 39 publications

Antimicrobial Activities of Some Synthetic Flavonoids

Antimicrobial Activities of Some Synthetic Flavonoids

Chalcones: Versatile intermediates in heterocyclic synthesis

Synthesis and Biological Evaluation of Flavonoids as Antiacetyl- cholinesterase Agent

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