Synthesis of a salbutamol dimer

Acid-Catalyzed Synthesis of Methylene-Bridged (S)-Tyrosine−Phenol Dimers

“…2,2′-Methylenebisphenols (Figure 1) are synthesized via acid-catalyzed procedures employing o-hydroxymethylphenols and phenols. Their ease of synthesis has undoubtedly contributed to their widespread use as: Novolac resins, 1 metalcoordinating complexes, 2 Salbutamol dimers, 3 asymmetric catalysts, 4 calix [4]arene precursors, 5 host-guest entities, 6 and anti-cancer agents. 7 Our strategy toward synthesizing 1-6 included two parts: (1) a base-catalyzed hydroxymethylation reaction between a (S)tyrosine derivative and formaldehyde and (2) an acid-catalyzed reaction between the previously synthesized intermediate and a phenol.…”

“…2,2‘-Methylenebisphenols (Figure ) are synthesized via acid-catalyzed procedures employing o -hydroxymethylphenols and phenols. Their ease of synthesis has undoubtedly contributed to their widespread use as: Novolac resins, metal-coordinating complexes, Salbutamol dimers, asymmetric catalysts, calix[4]arene precursors, host−guest entities, and anti-cancer agents 1 ( S )-Tyrosine-derived dimers and their starting materials.…”