Synthesis of aminothiazoles: polymer-supported approaches

Patil, Rajendra; Chavan, Jagdish; Beldar, Anil

doi:10.1039/c7ra00790f

Cited by 15 publications

(13 citation statements)

References 112 publications

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“…The infrared spectra were `recorded on Shimadzu FT-IR spectrophotometer (Japan). 1 H NMR spectra were measured on a Bruker 400 MHz spectrometer (Turkey) in deuterated dimethyl sulfoxide (DMSO-d6) as a solvent and tetramethylsilane (TMS) as an internal standard. For in silico protein-ligand docking simulation, Mcule docking online.…”

Section: Methodsmentioning

confidence: 99%

“…The 2-aminothiazole agents are associated with a broad spectrum of biological properties, including anticonvulsant [1], antiviral [2], antimicrobial [3], antituberculous [4], antimalarial [5], anticancer [6], and hypertension [7], are just a few of the biological features related with 2-aminothiazole compounds. Cefdinir is a semi-synthetic broad-spectrum antibiotic 3 rd generation cephalosporin [8], and several marketed medicines for various diseases contain 2aminothiazole moieties as illustrated in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

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Docking and synthesis of some 2-aminothiazole derivatives as antimicrobial agents

Abdu-Rahem¹,

Ahmad²,

Abachi

2021

Egypt. J. Chem.

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The 2-aminothiazole compounds are medicinally important agents due to their broad spectrum of biological activities. This study aims to design new 2-aminothiazole derivatives, docking, and synthesis via several steps and identified d concerning their The bioactivities of the synthesized compounds were evaluate using physical and spectroscopic techniques. Escherichia , Enterobact aerogenes were screened against five bacterial strains, antimicrobial activities against Candida and two types of fungal strain Pseudomonas aeruginosa, Staphylococcus aureus , Enterococcus faecalis , coli . Cryptococcus neoformans var. grubii and albicans K albicans. C.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Docking and synthesis of some 2-aminothiazole derivatives as antimicrobial agents

Abdu-Rahem¹,

Ahmad²,

Abachi

2021

Egypt. J. Chem.

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“…The available literature reveals that some research groups have reported polymer supported solid phase synthesis [36,37] as well as polymers as catalyst and catalyst support [38] for synthesis of bioactive heterocyclic compounds. In this review, for the first-time efforts are made to compile all the literature regarding the role of polymers for the improvements in the Friedlander quinoline synthesis.…”

Section: Scopementioning

confidence: 99%

Advances in polymer based Friedlander quinoline synthesis

Patil¹,

Chavan²,

Patel³

et al. 2021

Turk J Chem

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Nitrogen containing heterocyclic compounds has acquired their remarkable and distinct place in the wide area of organic synthesis due to the broad range of applications. Among them, quinoline motifs have attracted researchers in the synthetic chemistry because of its presence in the large number of pharmacologically active compounds. Different methods for synthesis of quinoline derivatives are reported, among them the Friedlander synthesis have provided comparatively more efficient approach. Many of the reported conventional Friedlander methodologies have some problems such as difficult product isolation procedures, poor yields and use of expensive catalysts etc. Recently, polymer or solid supported synthetic approaches have attracted the attention of researchers because of their easy execution, greater selectivity, increased product yields, simple work-up procedures, recoverability and reusability of the catalysts. In consideration with the advantages of polymer supported synthetic strategies, the proposed review covers the role of polymers in the Friedlander synthesis; 2 which may use polymers of organic, inorganic or hybrid in nature and of nano level as well.

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“…There are many substituted thiazole-containing heterocycles covering a wide range of therapeutic targets including antimicrobial, anticancer, anti-inflammatory and anti-HIV. Aminothiazole scaffolds are important structural units in medicinal chemistry as they have shown antitumor [ 1 , 2 , 3 ], antiviral [ 4 , 5 , 6 ], antibacterial [ 7 , 8 , 9 ], anti-prion [ 10 ], psychotropic [ 11 ], anti-allergic [ 12 ], anti-hypertensive [ 13 ], anti-inflammatory [ 14 , 15 ], antifungal [ 16 ], antitubercular [ 17 , 18 ], anti-HIV [ 19 ], pesticidal [ 20 ], antiprotozoal [ 21 ], antipyretic [ 22 ], antioxidative [ 23 ] and analgesic activities [ 24 ]. Aminothiazole compounds act as ligands of estrogen receptors [ 25 ] and afford a new group of adenosine receptor antagonists [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

2021

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Amongst sulfur- and nitrogen-containing heterocyclic compounds, the 2-aminothiazole scaffold is one of the characteristic structures in drug development as this essential revelation has several biological activities abiding it to act as an anticancer, antioxidant, antimicrobial and anti-inflammatory agent, among other things. Additionally, various 2-aminothiazole-based derivatives as medical drugs have been broadly used to remedy different kinds of diseases with high therapeutic influence, which has led to their wide innovations. Owing to their wide scale of biological activities, their structural variations have produced attention amongst medicinal chemists. The present review highlights the recently synthesized 2-aminothiazole-containing compounds in the last thirteen years (2008–2020). The originality of this proposal is based on the synthetic strategies developed to access the novel 2-aminothiazole derivatives (N-substituted, 3-substituted, 4-substituted, multi-substituted, aryl/alkyl substituents or acyl/other substituents). The literature reports many synthetic pathways of these 2-aminothiazoles associated with four different biological activities (anticancer, antioxidant, antimicrobial and anti-inflammatory activities). It is wished that this review will be accommodating for new views in the expedition for rationalistic designs of 2-aminothiazole-based medical synthetic pathways.

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Synthesis of aminothiazoles: polymer-supported approaches

Cited by 15 publications

References 112 publications

Docking and synthesis of some 2-aminothiazole derivatives as antimicrobial agents

Docking and synthesis of some 2-aminothiazole derivatives as antimicrobial agents

Advances in polymer based Friedlander quinoline synthesis

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

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