Synthesis of antibacterial TiO2/PLGA composite biofilms

Wu, Jin-Shang; Li, Ching-Wen; Tsai, Ching‐Hsiu; Chou, Chih-Wei; Chen, Dar‐Ren; Wang, Gou‐Jen

doi:10.1016/j.nano.2014.01.002

Cited by 52 publications

(29 citation statements)

References 45 publications

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“…4(a) displays the SEM image of the top surfaces of composite film. Notably, there are some aggregations of white rods observed on the film, which may be attributed to the absorbed TiO 2 or the unencapsulted TiO 2 [29]. In the SEM image of film cross-section ( Fig.…”

Section: Film Morphologymentioning

confidence: 95%

Facile synthesis of casein-based TiO 2 nanocomposite for self-cleaning and high covering coatings: Insights from TiO 2 dosage

Fan

et al. 2016

Progress in Organic Coatings

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Section: Film Morphologymentioning

confidence: 95%

Facile synthesis of casein-based TiO 2 nanocomposite for self-cleaning and high covering coatings: Insights from TiO 2 dosage

Fan

et al. 2016

Progress in Organic Coatings

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“…The same research group in a further study reported the activity of these Ag-TiO 2 coatings for long term (28 days) (187). TiO 2 coatings were also applied on silicone catheters, obtaining an interesting bactericidal effect against E. coli (188), and on PLGA wound dressings, achieving efficient antibacterial activity against S. aureus and E. coli combined with good survival rate of keratinocytes and fibroblasts (189).…”

Section: •-mentioning

confidence: 97%

Antifouling and antimicrobial biomaterials: an overview

Francolini

Vuotto

Piozzi

et al. 2017

APMIS

264

220

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The use of implantable medical devices is a common and indispensable part of medical care for both diagnostic and therapeutic purposes. However, as side effect, the implant of medical devices quite often leads to the occurrence of difficult‐to‐treat infections, as a consequence of the colonization of their abiotic surfaces by biofilm‐growing microorganisms increasingly resistant to antimicrobial therapies. A promising strategy to combat device‐related infections is based on anti‐infective biomaterials that either repel microbes, so they cannot attach to the device surfaces, or kill them in the surrounding areas. In general, such biomaterials are characterized by antifouling coatings, exhibiting low adhesion or even repellent properties towards microorganisms, or antimicrobial coatings, able to kill microbes approaching the surface. In this light, the present overview will address the development in the last two decades of antifouling and antimicrobial biomaterials designed to potentially limit the initial stages of microbial adhesion, as well as the microbial growth and biofilm formation on medical device surfaces.

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“…Titanium dioxide (TiO 2 ) is a harmless white pigment used in paints, coatings, plastic, article, ink, and cosmetic products such as sunscreen and toothpaste . TiO 2 also exerts cytostatic and bactericidal effects with visible or UV light activation that are valuable for various biological and medical applications . In one study, TiO 2 nanoparticles prepared using the common herb Origanum vulgare promoted healing of clear wounds in Wistar albino rats, although the mechanism is unknown …”

Section: Introductionmentioning

confidence: 99%

“…1 TiO 2 also exerts cytostatic and bactericidal effects with visible or UV light activation that are valuable for various biological and medical applications. [2][3][4] In one study, TiO 2 nanoparticles prepared using the common herb Origanum vulgare promoted healing of clear wounds in Wistar albino rats, although the mechanism is unknown. 5 Ultrasound is generally harmless and has been used as a clinical diagnostic tool as well as an alternative therapeutic approach to treat cancer and bone fractures and promote wound healing.…”

Section: Introductionmentioning

confidence: 99%

Acceleration of wound healing by ultrasound activation of TiO₂ in Escherichia coli‐infected wounds in mice

et al. 2016

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Surgical site infections continue to be a common complication affecting surgical prognosis. Reactive oxygen species (ROS) are generated by ultrasound-irradiated titanium dioxide (TiO ) (UIT). Although excessive ROS production can cause cell damage, ROS at physiological levels mediate beneficial cellular responses, including angiogenesis. This study investigated whether UIT can promote healing of Escherichia coli-infected wounds. We used TiO and ultrasound irradiation using an ultrasonography machine at a frequency of 1.0 MHz and intensity of 0.4 W cm . These levels are not bactericidal in vitro; therefore, we could study the effect of UIT on E. coli survival without interference of ultrasound effects. The number of cluster of differentiation 31-positive blood vessels, which are indicative of angiogenesis, was decreased by bacterial infection, and increased at the wound edges in the UIT-treated infected wounds, suggesting upregulation of neovascularization by UIT. Although UIT treatment did not decrease E. coli survival in vivo, it promoted healing of the infected wounds as evidenced by a significant decrease in the wound area in the UIT-treated mice. Our findings demonstrate that UIT promotes wound healing in surgical site infections and suggest beneficial use of the UIT-based approach as a novel therapeutic method to treat infected surgical wounds. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2344-2351, 2017.

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Synthesis of antibacterial TiO2/PLGA composite biofilms

Cited by 52 publications

References 45 publications

Facile synthesis of casein-based TiO 2 nanocomposite for self-cleaning and high covering coatings: Insights from TiO 2 dosage

Facile synthesis of casein-based TiO 2 nanocomposite for self-cleaning and high covering coatings: Insights from TiO 2 dosage

Antifouling and antimicrobial biomaterials: an overview

Acceleration of wound healing by ultrasound activation of TiO₂ in Escherichia coli‐infected wounds in mice

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Synthesis of antibacterial TiO2/PLGA composite biofilms

Cited by 52 publications

References 45 publications

Facile synthesis of casein-based TiO 2 nanocomposite for self-cleaning and high covering coatings: Insights from TiO 2 dosage

Facile synthesis of casein-based TiO 2 nanocomposite for self-cleaning and high covering coatings: Insights from TiO 2 dosage

Antifouling and antimicrobial biomaterials: an overview

Acceleration of wound healing by ultrasound activation of TiO2 in Escherichia coli‐infected wounds in mice

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Acceleration of wound healing by ultrasound activation of TiO₂ in Escherichia coli‐infected wounds in mice