Synthesis of copper and zinc 2-(pyridin-2-yl)imidazo[1,2-a]pyridine complexes and their potential anticancer activity

Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function

“…Currently, the development of metal complexes with nonplatinum central atoms including ruthenium [11], gold [12], silver [13], copper [14], zinc [15], Manganese [16], nickel [17], iridium [18] and cobalt [19] has been one of the hottest emerging areas of anticancer drug research. Among these, carbonyl cobalt complex has strong properties of cancer prevention including tumour growth/metastasis suppression [20], antiproliferative [21], DNA cleavage [22], apoptotic induction [23] and autophagy [8], which was more active than cisplatin on the human breast tumour cell lines (MCF-7 and MDA-MB-231) [24,25] and ovarian cancer cells (SKOV3/ DDP) [26].…”

Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes

“…In addition to the expected biological properties of the Schiff base compounds, [30][31][32][33][34][35] binding the cobalt, copper and zinc atoms to this unit make these complexes a good prospect for biologically active compounds [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] (31)(32)(33)(34)(35) for zinc, 36-40 for cobalt, 41-45 for copper). For the study of the biological activities of new ligand (H 3 L Br ) and its complexes 1-3, docking calculations were run to investigate the possibility of interaction between these compounds with nine protein targets, including: BRAF kinase, cathepsin B (CatB), DNA gyrase, histone deacetylase (HDAC7), recombinant human albumin (rHA), ribonucleotide reductases (RNR), thioredoxin reductase (TrxR), thymidylate synthase (TS), topoisomerase II (Top II).…”

Green Synthesis, Characterization and Antidiabetic Activity of 2-Substituted Aryl/Alkyl-N-Aryl/Alkyl Imidazo[1,2-a]pyridin-3-amine Derivatives

“…Xu et al [28] reported the synthesis of compounds 6a, 6b using zinc iodide catalyzed conditions, Lacerda et al [29] synthesized compound 6c, 7a using AcOH catalyzed reaction condition, Shinde et al [31] reported the synthesis of compound 6d using LaCl3·7H2O. Kiselyov [32] reported the synthesis of compound 6e using N-fluoropyridinium salts, Dam et al [33] reported the synthesis of 7d using Montmorillonite K-10 clay as catalyst. To the best of our knowledge, the synthesis of compounds 6f, 7b, 7c, 7e-7f are new and have not been reported in the literature so far.…”