Synthesis of cubic LiNbO3 nanoparticles and their application in vitro bioimaging

Wang, Y.; Zhou, Xinzhu; Chen, Z.; Cai, Bin; Ye, Z. Z.; Gao, Changyou; Huang, Jingyun

doi:10.1007/s00339-014-8630-x

Cited by 32 publications

(24 citation statements)

References 30 publications

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“…[20][21][22] Recently, LiNbO3 nanoparticles have been used as bio-imaging probes to image cells by taking advantage of the exceptional SHG properties of these particles. [23][24][25] A wider utilization of nanoparticles as SHG bio-imaging probes will require their dimensions to be below 100 nm. 26,27 The NLO properties of nanomaterials can also depend on their size, shape, and/or specific chemical composition.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Lithium Niobate Nanocrystals with Size Focusing through an Ostwald Ripening Process

Ali

Gates

2018

Chem. Mater.

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A simple surfactant assisted solution-phase approach is demonstrated here for the preparation of lithium niobate (LiNbO3) nanoparticles with an average size of 30 nm. This solution-phase process results in the formation of crystalline, uniform nanoparticles of LiNbO3 at 220 o C with an optimal reaction time of 36 h. Advantages of this method also include the preparation of crystalline nanoparticles of LiNbO3 without the need for further heat treatment or the use of an inert atmosphere. The growth of these nanoparticles began with a controlled agglomeration of nuclei. The reaction subsequently underwent a process of oriented attachment and Ostwald ripening, which dominated and controlled the further growth of the nanoparticles. These processes produced single-crystalline nanoparticles of LiNbO3. The average dimensions of the nanoparticles were tuned from 30 to 95 nm by increasing the reaction time of the solvothermal process. The LiNbO3 nanoparticles were characterized using transmission electron microscopy (TEM), selected area electron diffraction (SAED), high resolution TEM, X-ray diffraction, and Raman spectroscopy techniques. The nanoparticles were also confirmed to be optically active for second harmonic generation (SHG). These particles could enable further development of SHG based microscopy techniques.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Lithium Niobate Nanocrystals with Size Focusing through an Ostwald Ripening Process

Ali

Gates

2018

Chem. Mater.

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“…Several authors have demonstrated the absence of bleaching, quenching, and blinking in HNPs response [24,25,37] and highlighted the benefits for imaging in terms of signal-tonoise ratio and long-term monitoring of evolving structures [53,54]. Indeed most mechanisms of signal intensity decay and/or variations over time are related to the excitation of resonant electronic states.…”

Section: Photo-stabilitymentioning

confidence: 99%

“…Alternatively, LiNbO 3 can be synthesized by reduction of niobium salts and hydrolysis with LiH [23]. Other authors have proposed a molten salt approach using KNbO 3 as precursor [24]. Note also that colloidal suspensions of KNbO 3 HNPs have been recently commercialized (TiBio Sagl, Comano, Switzerland).…”

Section: Synthesis and Preparation Of Colloidal Suspensionsmentioning

confidence: 99%

Harmonic nanoparticles: noncentrosymmetric metal oxides for nonlinear optics

Rogov

Mugnier

Bonacina

2015

J. Opt.

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The combination of nonlinear optics and nanotechnology is an extremely rich scientific domain yet widely unexplored. We present here a review of recent optical investigations on noncentrosymmetric oxide nanoparticles with a large χ (2) response, often referred to as harmonic nanoparticles (HNPs). HNPs feature a series of properties which distinguish them from other photonics nanoprobes (quantum dots, up-conversion nanoparticles, noble metal particles). HNPs emission is inherently nonlinear and based on the efficient generation of harmonics as opposed to fluorescence or surface plasmon scattering. In addition, the fully coherent signal emitted by HNPs together with their polarization sensitive response and absence of resonant interaction make them appealing for several applications ranging from multi-photon (infrared) microscopy and holography, to cell tracking and sensing.

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“…190 In addition to the popular ZnO and BaTiO 3 NPs, cubic LiNbO 3 NPs and colloidal KTiOPO 4 (KTP) nanocrystals emitted SHG that peaked at 520 nm (with a pulsed laser at 1040 nm) and 512 nm (1024 nm wavelength, 80 MHz repetition rate and 100 fs pulse duration), respectively, which could be used to track mice macrophages. 185 Considering their biocompatibility, the cytotoxicity of five harmonic NPs (KNbO 3 , LiNbO 3 , BaTiO 3 , KTP and Zn) was dose dependent on human adenocarcinoma (A549), adenosquamous carcinoma (HTB-178), lung squamous carcinoma (HTB-182) and non-tumoral BEAS-2B cells. 191 The optical properties of these NPs in harmonic conversion are very similar.…”

Section: Lanthanide-doped Upconverting Nps (Ucnps)mentioning

confidence: 99%

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

et al. 2016

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With the development of nonlinear optics and new imaging methods, near-infrared (NIR) light can excite contrast agents to probe biological specimens both functionally and structurally with a deeper imaging depth and a higher spatial resolution than linear optical approaches. There is considerable and growing interest in how biological specimens respond to NIR light. Moreover, the visible absorption band of most functional nanomaterials becomes NIR-excitable through multiphoton processes, thus allowing multifunctional imaging and combined therapy with noble metal and magnetic nanoparticles both in vitro and in vivo. A groundbreaking example is the use of different laser techniques to excite single-type NIR-absorbing/emitting nanomaterials to produce multiphoton emission by femtosecond lasers using either a remote control system for photodynamic therapy or photo-induced chemical bond dissociation. These techniques provided superior anatomical resolution and detection sensitivity for in vivo tumor-targeted imaging than those offered by conventional methods. Here we summarize the most recent progress in the development of smart NIR-absorbing/emitting nanomaterials for in vivo bioapplications.

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Synthesis of cubic LiNbO3 nanoparticles and their application in vitro bioimaging

Cited by 32 publications

References 30 publications

Synthesis of Lithium Niobate Nanocrystals with Size Focusing through an Ostwald Ripening Process

Synthesis of Lithium Niobate Nanocrystals with Size Focusing through an Ostwald Ripening Process

Harmonic nanoparticles: noncentrosymmetric metal oxides for nonlinear optics

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

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