Synthesis of Cytosine Derivatives and Study of their Alkylation under Mild Conditions

Ethynyl Side Chain Hydration during Synthesis and Workup of “Clickable” Oligonucleotides: Bypassing Acetyl Group Formation by Triisopropylsilyl Protection

“…ESI-TOF: m / z calcd for 22 C 6 H 5 N 3 O [M + Na] + 158.0325, found 158.0331; m / z calcd for 23 C 6 H 7 N 3 O 2 [M + Na] + 176.0430, found 176.0438. The obtained NMR data correspond to literature values reported earlier. , …”

“…In the case of eth dC ( 2 ), the situation is different. Here, acid treatment led to cleavage of the N -glycosylic bond and formation of a 1:1 mixture of 5-ethynylcytosine ( 22 ) and 5-acetylcytosine ( 23 ) in 84% overall yield. Both components were identified by NMR spectra and mass data.…”

The Convenient Synthesis of 11‐Methyl‐3,8‐disubstituted‐12‐aryl‐3,4,7,8,9,12‐hexahydro‐1H‐chromeno[2,3‐b]quinoline‐1,10(2H)‐dione Derivatives

“…In this study, the 2-arylidene-3-oxobutanenitrile derivatives 2 used for the current studies were easily prepared by the Knoevenagel condensation between aldehydes and 3-oxobutanenitrile 1 [10], which was obtained by acid hydrolysis of b-aminocrotononitrile [11,12]. 3-Acetyl-2amino-4H-chromen-5(6H)-one derivatives 3 were synthesized by reaction of 2-arylidene-3-oxobutanenitrile 2 and 5,5-dimethyl-1,3-cyclohexanedione in ethylene glycol.…”