Synthesis of dual-functional targeting probes for cancer theranostics based on iron oxide nanoparticles coated by centipede-like polymer connected with pH-responsive anticancer drug

Zhao, Haochen; Li, Zhiping; Yang, Bo; Wang, Jingyuan; Li, Yapeng

doi:10.1080/09205063.2015.1080900

Cited by 12 publications

(4 citation statements)

References 29 publications

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“…Several groups of coating agents are used to modify the surface chemistry of iron oxide NPs to extend the time of blood circulation and reduce the immune response, and thus clear them from the body [132]. Likewise, appropriate surface coating lets iron oxide NPs disperse into homogenous ferrofluids and thus improve their stability [133].…”

Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Yazdi¹,

Sepehrizadeh²,

Mahdavi³

et al. 2016

Nano BioMed ENG

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Nanoparticles have comprehensively affected various sights of human life. Through the wide range of claims about nanosized particles and their functions, biomedical applications are of much interest among health care researchers due to the nanoparticles' potential for use in the process of disease diagnosis, control and treatment. In this regard, inorganic nanoparticles, which have high potential in diagnostic and therapeutic systems, have recently received much attention in oncology. Although inorganic nanoparticles initially seemed an appropriate tool for cancer imaging and diagnosis, their ability to attack cancerous cells as anticancer drugs or carriers in other drugs has also demonstrated promising results. The present review primarily provides a brief survey of various studies in which metal nanoparticles such as gold, silver, iron oxide, and metalloid nanoparticles viz. tellurium and bismuth were exploited for therapeutic or diagnostic purposes in oncology. Then the application of selenium nanoparticles as a therapeutic agent against cancer in in vitro and in vivo studies is reviewed in detail. Although inorganic nanoparticles seem to be useful tools for cancer imaging and diagnosis, their potential for attacking cancerous cells as anticancer substances or even carriers for anticancer medications should not be underestimated.

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Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Yazdi¹,

Sepehrizadeh²,

Mahdavi³

et al. 2016

Nano BioMed ENG

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“…The main challenge in cancer therapy is delivery of anticancer drugs selectively to the cancer cells without interacting with the normal body cells. In recent decades, nanocarriers have attracted significant attention in anticancer drug delivery. , Among the various nanocarriers applied in tumor therapy, magnetic nanocarriers have been more desirable due to their magnetic properties . The anticancer loaded magnetic nanocarriers can be easily transported to the tumor site using an external magnet which reduces the side effects.…”

Section: Introductionmentioning

confidence: 99%

Delivery of Hydrophobic Anticancer Drugs by Hydrophobically Modified Alginate Based Magnetic Nanocarrier

Pourjavadi

Amin

Hosseini

2018

Ind. Eng. Chem. Res.

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Since most of the anticancer drugs have low solubility in water, the clinical use of them is limited unless by some modification the solubility increases or the drug is carried with a soluble compartment. To solve this problem, we prepared a magnetic nanocarrier with a hydrophobic surface based on oleic acid chains in which hydrophobic drug molecules such as doxorubicin hydrochloride (DOX) and paclitaxel (PTX) are easily adsorbed onto the surface. Since the drug molecules are physically adsorbed on the surface, large amounts of DOX (282 mg·g–1) and PTX (316 mg·g–1) were immobilized onto the nanocarrier. Then, the surface of the drug loaded magnetic core was covered by a smart pH-sensitive shell based on sodium alginate. The alginate shell around the magnetic core increased the stability and biocompatibility of the drug loaded nanocarrier. The results of the drug release profile showed that the drug molecules were released faster in acidic medium than in the neutral medium. The MTT assay of the nanocarrier showed low toxicity toward MCF-7 and HeLa cells, while the drug loaded nanocarrier had high toxicity, even higher than the free drugs. Owing to these advantages, the resulting nanocarrier exhibits a promising potential for delivery of hydrophobic drug molecules in clinical applications.

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“…Among MNPs, the most commonly used particles are certainly based on iron oxides [100,101]. The latter were combined with various drugs (e.g., epirubicin) [176] and are on their own capable of being used to induce magnetic hyperthermia [158,159], and since they are mostly functionalized in order to prevent agglomeration [195], their surface is suitable for anchoring different targeting moieties (e.g., antibodies) [196,197].…”

Section: Potential Impact Of Nanotechnology On Future Skin Cancer Trementioning

confidence: 99%

Skin Cancer and Its Treatment: Novel Treatment Approaches with Emphasis on Nanotechnology

Orthaber

Pristovnik

Skok

et al. 2017

Journal of Nanomaterials

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The life expectancy in the Western world is increasing for a long time, which is the courtesy of a higher life standard, a more thorough hygiene, and, of course, the progress of modern medicine. Nevertheless, one of the illnesses that still proves to be a great challenge regardless of the recent advancements in medicine is cancer. Skin cancer is, according to the World Health Organization, the most common malignancy for the white population. The beginning of the paper offers a brief overview of the latest available information concerning epidemiology, aetiology, diagnostics, and treatment options for skin cancer, whereas the rest of the article deals with modern approaches to skin cancer treatment, highlighting recent development of nanotechnology based treatment approaches. Among these, we focus especially on the newest nanotechnological approaches combined with chemotherapy, a field which specialises in target specificity, drug release control, and real time monitoring with the goal being to diminish unwanted side effects and their severity, achieving a cheaper treatment and a generally more efficient chemotherapy. The field of nanotechnology is a rapidly developing one, judging by already approved clinical studies or by new theranostic agents that combine both the therapeutic and diagnostic modalities.

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Synthesis of dual-functional targeting probes for cancer theranostics based on iron oxide nanoparticles coated by centipede-like polymer connected with pH-responsive anticancer drug

Cited by 12 publications

References 29 publications

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Delivery of Hydrophobic Anticancer Drugs by Hydrophobically Modified Alginate Based Magnetic Nanocarrier

Skin Cancer and Its Treatment: Novel Treatment Approaches with Emphasis on Nanotechnology

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