Synthesis of Dual‐Stimuli‐Responsive Microcontainers with Two Payloads in Different Storage Spaces for Preprogrammable Release

Abstract

Stimuli-responsive microcontainers have become am ajor topic of interest, from fundamental aspects to applications in materials science.H owever,m icrocontainers that enable the loading of multiple species and programmable release are mostly unexplored. Herein, we describe the design and synthesis of ad ual-responsive organic/inorganic hybrid microcontainer with two payloads in separate storage spaces that is formed by the rapid UV-initiated polymerization of Pickering emulsions.The stellate mesopore silica nanoparticles with poly(N-isopropylacrylamide) grafted inside the mesopores were loaded with one compound (Nile red) and used as Pickering emulsifiers to stabilizeo il-in-water droplets.U pon UV irradiation, pH-responsive monomers were polymerized in the presence of 5(6)-carboxyfluorescein diacetate (CFDA) to form hybrid colloidal microcontainers.The release of Nile red and CFDAc ould be selectively activated by changing the temperature or pH value.

Hollow structures as drug carriers: Recognition, response, and release

“…If different stimuli are applied to the two parts, the difference in spatial position combined with the response to the environmental stimulus will work together to drive a more controllable sequential release [165,166]. For example, Cong et al synthesized a hybrid dual-responsive microcontainer, in which the pH-responsive polymer microspheres were loaded with 5(6)carboxyfluorescein diacetate (CFDA) [165].…”

Trojan‐Horse‐Like Stimuli‐Responsive Microcapsules

“…Moreover, for the assembled copolymer shells, their poor stability against osmotic pressure or mechanical stress usually causes undesired shell rupture and content release . Recently, from Pickering emulsion drops, microcapsules, containing a more stable pH‐responsive hydrogel shell, decorated with porous silica nanoparticles modified by thermo‐responsive polymers, have been created for programmed sequential release . Nevertheless, the microcapsules show nonuniform size and limited control of loading amount of contents in the silica nanoparticles due to limited shell surface.…”

Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

“…Various polymers with physicochemical response to stimuli can be precisely developed as potential drug-loaded systems. [1][2][3][4] Stimuli behaviors are studied at the target site through response to different environmental stimuli such as temperature, pH, electric field, and certain chemical substances. [5][6][7] Poly(N-isopropylacrylamide) (PNIPAM) is a typical example of thermosensitive polymers, and it exhibits a lower critical solution temperature (LCST) of about 32 C. 5,6 However, from the application point of view, the normal human body temperature is far higher than the LCST of PNIPAM.…”

“…In recent years, there has been considerable interest in exploring polymer nanogels as effective drug delivery applications. Various polymers with physicochemical response to stimuli can be precisely developed as potential drug‐loaded systems . Stimuli behaviors are studied at the target site through response to different environmental stimuli such as temperature, pH, electric field, and certain chemical substances .…”