Synthesis of fatty acid Schiff base esters as potential antimicrobial and chemotherapeutic agents

Mohini, Y.; Karuna, Mallampalli Sri Lakshmi; Kumar, C. Ganesh; Poornima, M.; Sujitha, Pombala

doi:10.1007/s00044-012-0450-y

Cited by 14 publications

(7 citation statements)

References 17 publications

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“…Schiff base was prepared by a mixture of equimolar quantities of 4-hydroxy benzaldehyde with 3-aminomethyl pyridine in absolute ethanol under reflux to give the corresponding Schiff base [16]. The 1 H NMR spectra of Schiff base showed a signal at 8.5-8.6 ppm which confirmed the proton indicating the presence of azomethine group (-CH=N).…”

Section: Resultsmentioning

confidence: 94%

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Synthesis and characterization of new fatty Schiff base ethers of 4-((pyridin-3-ylmethylimino)methyl)phenol

2014

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Section: Resultsmentioning

confidence: 94%

“…Schiff base (1) {4-(pyridine-3-methylimino) methyl phenol} was prepared by the condensation of 4-hydroxy benzaldehyde (2 mmol) and 3-aminomethyl pyridine (2 mmol) in absolute ethanol for 6 h at 80-85 °C (Scheme 1) which yielded Schiff base [16]. …”

Section: General Procedures For the Synthesis Of Schiff Base 4-((pyridmentioning

confidence: 99%

Synthesis and characterization of new fatty Schiff base ethers of 4-((pyridin-3-ylmethylimino)methyl)phenol

2014

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“…The factors such as planarity of ligands, coordination geometry and flexible valence are the root causes of binding modes of DNA and in antimicrobial activity, nature of metal ion, hydrophilicity, lipophilicity and coordination sites also have considerable influence on activity. The design and development of potential therapeutic agents, particularly those designed to target nucleic acids site can lead to new approaches to novel therapeutic agents for cancer and antimicrobial activities [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural characterization and biological properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of tetradentate Schiff bases

Vedanayaki¹,

Jayaseelan²

2016

Eur. J. Chem.

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New binucleating Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of the prepared ligands with N4 donor were synthesized. The ligands are obtained by the condensation of paraphenylenediamine with diacetylmonoxime and benzilmonoxime. The synthesized ligands and their metal complexes were characterized by elemental analysis and various spectroscopic techniques. The Cu(II), Ni(II) complexes were square planar, VO(II) complex was square pyramidal, whereas Mn(II), Zn(II) complexes were of tedrahedral geometry. Both the ligands and their metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration method. The results showed that the metal complexes were found to be more active than free ligand. The DNA binding capacities of all the complexes were analyzed by using UV absorption spectra. The DNA cleaving capacities of all complexes were analyzed by agarose gel electrophoresis method against pBR322 DNA. KEYWORDS

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“…In view of the increased threat from these drugresistant Gram-positive and Gram-negative bacterial strains and also Candida strains, there is a continuous demand and perusal to identify new antimicrobial agents. Several reports claim that numerous potent biological activities such as, insect repellent 3 , antibacterial [4][5][6][7] , pesticidal 8 , antifungal [9][10][11] , anti-inflammation 12 , antioxidant…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IJPSR

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A series of novel cholesteryl lactate-fatty acid conjugates (4a-i) were prepared by esterification of cholesterol with lactic acid, followed by coupling hydroxyl group of cholesteryl lactate with -COOH group of fatty acids including, saturated fatty acids of varying carbon chain of C 10 -C 18 , unsaturated fatty acids like 10-undecenoic, oleic ((9Z)-octadec-9-enoic), ricinoleic ((9Z,12R)-12-hydroxyoctadec-9-enoic) and 11-bromoundecanoic acid. Cholesteryl lactate-fatty acid conjugates were characterized by spectroscopic techniques like FT-IR, 1H-NMR, 13C-NMR, ESI-MS and HRMS. All the synthesized compounds were tested for their antimicrobial activity against a panel of seven bacterial strains like Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121, Micrococcus luteus MTCC 2470, Klebsiella planticola MTCC 530, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 2453 and fungal strain like Candida albicans. Among them, the compounds with unsaturation (4f and 4h), and functional groups like bromine and hydroxyl group (4g and 4i) showed good antibacterial activity. But, promising activity was observed against Staphylococcus aureus MTCC 96 strain ranging from 7.8-15.6 µg/ml. These compounds (4f-i) are also exhibited good to moderate antifungal activity against different Candida strains ranging between 7.8-31.2 µg/ml.

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Synthesis of fatty acid Schiff base esters as potential antimicrobial and chemotherapeutic agents

Cited by 14 publications

References 17 publications

Synthesis and characterization of new fatty Schiff base ethers of 4-((pyridin-3-ylmethylimino)methyl)phenol

Synthesis and characterization of new fatty Schiff base ethers of 4-((pyridin-3-ylmethylimino)methyl)phenol

Synthesis, structural characterization and biological properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of tetradentate Schiff bases

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