Synthesis of Ferrocene Derivatives Allowing Linear Free Energy Studies of Redox Potentials

Abstract

A series of ferrocene derivatives, which have diverse redox potentials modulated by functional groups, have been synthesized as potential ‘multi‐potential’ probes. A Hammett constant analysis revealed a linear free energy correlation between the redox potentials and the electron density of the ferrocene derivatives as determined by the choice of functional group used to modify the ferrocene core.

An Organophosphorus(III)-Selective Chemodosimeter for the Ratiometric Electrochemical Detection of Phosphines

“…By obtaining direct conversions from the sample, systematic and sampling errors are reduced. Ferrocene-based probes are specifically and commonly used, due to their synthetic utility [17][18][19], aerobic and aqueous stability [20], and tunable oxidation potential [21,22]. Thus, we believe that we could utilize these advantageous properties to synthesize an electrochemical probe purposed for the development of a point-of-care solution for the detection of potentially highly-toxic organophosphorus(III) compounds.…”