Synthesis of gold nanoparticles and nanoclusters in a supramolecular gel and their applications in catalytic reduction of p-nitrophenol to p-aminophenol and Hg(<scp>ii</scp>) sensing

Kumar, Deepak

doi:10.1039/c4ra07532c

Cited by 22 publications

(24 citation statements)

References 92 publications

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“…To this end, Fmoc‐FuF scaffolds were cultured with 3T3 cells and tested by Live/Dead analysis in situ, 48 h following seeding. Living cells were abundantly found on the gel scaffold (Figure g; control condition is shown in Figure S9, Supporting Information), showing that the biocompatibility of the Fmoc‐FuF hydrogel is similar to that of Fmoc‐FF, and in line with the reported biocompatibility of nonpeptidic urea–modified supramolecular hydrogels and covalent polymeric materials . Hence, the Fmoc‐FuF hydrogel can support the attachment of cells, as required for biomedical applications .…”

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confidence: 72%

Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification

et al. 2019

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Peptidomimetic low‐molecular‐weight hydrogelators, a class of peptide‐like molecules with various backbone amide modifications, typically give rise to hydrogels of diverse properties and increased stability compared to peptide hydrogelators. Here, a new peptidomimetic low‐molecular‐weight hydrogelator is designed based on the well‐studied N ‐fluorenylmethoxycarbonyl diphenylalanine (Fmoc‐FF) peptide by replacing the amide bond with a frequently employed amide bond surrogate, the urea moiety, aiming to increase hydrogen bonding capabilities. This designed ureidopeptide, termed Fmoc—Phe—NHCONH—Phe—OH (Fmoc‐FuF), forms hydrogels with improved mechanical properties, as compared to those formed by the unmodified Fmoc‐FF. A combination of experimental and computational structural methods shows that hydrogen bonding and aromatic interactions facilitate Fmoc‐FuF gel formation. The Fmoc‐FuF hydrogel possesses properties favorable for biomedical applications, including shear thinning, self‐healing, and in vitro cellular biocompatibility. Additionally, the Fmoc‐FuF, but not Fmoc‐FF, hydrogel presents a range of functionalities useful for other applications, including antifouling, slow release of urea encapsulated in the gel at a high concentration, selective mechanical response to fluoride anions, and reduction of metal ions into catalytic nanoparticles. This study demonstrates how a simple backbone modification can enhance the mechanical properties and functional scope of a peptide hydrogel.

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confidence: 72%

Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification

et al. 2019

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“…[29] X-band EPR spectra before the start of reaction, shows a sharp band with g s = 2.26 and g ⊥ = 2.17 which is characteristic of Cu II ion (Figure 1b). [30] The decrease in intensity of the EPR signal recorded for the reaction mixture after 16 hours confirms the irreversible reduction of Cu II to Cu I during the reaction. Cu I being a d 10 ion, is diamagnetic.…”

Section: Resultsmentioning

confidence: 74%

An Insight into Nitromethane as an Organic Nitrile Alternative Source towards the Synthesis of Aryl Nitriles

et al. 2019

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Directed by an unusual in situ reduction of CuII, our protocol is a simple CuI‐mediated synthesis of aryl nitriles, with inexpensive and readily available nitromethane as the cyanating source, in moderate to good yields. Exhibiting a wide substrate scope, the method involves simple reaction conditions, is additive free with low catalyst loading. The plausible mechanism of cyanation of aryl halides is elucidated by a congregation of three cycles, namely the in situ reduction of CuII species by nitromethane, generation of HCN species from nitromethane and a regular organometallic pathway which releases the nitrile derivative. The detail of the mechanism of generation of CN– from nitromethane is computationally validated. Our protocol holds the distinction of involving a rarely encountered CuI catalytic species as well as facile in situ generation of nucleophilic CN– to yield synthetically useful aromatic nitriles.

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“…The cells undergoing apoptosis is marked by a series of events such as nuclear condensation and DNA fragmentation, which could be observed in the cells as small, irregular and textured Hoechst stained nuclei. [31] As illustrated in Figure S4 (a, b), untreated and nanoceria alone treated cells possessed intact nuclei, while in case of H 2 O 2 treated cells (Figure S4 (c)) significant nuclear condensation and DNA fragmentation corresponding to apoptosis was noticed. Moreover, the pre-treatment of cells with nanoceria prior to H 2 O 2 exposure (FigureS4 (d-i)), reduced the formation of apoptotic bodies, thus protect the cells from oxidative stress induced cell damage.…”

Section: Nuclear Fragmentation Analysis By Hoechst 33342mentioning

confidence: 89%

Therapeutic Nanozyme: Antioxidative and cytoprotective effects of nanoceria against hydrogen peroxide induced oxidative stress in fibroblast cells and in zebrafish

et al. 2016

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Biomimetic nanoparticles emerge as an auspicious class of antioxidative nano‐agents owing to their inherent catalytic properties. Among them, nanoceria revolutionizes the field of nanomedicine due to its astonishing antioxidant enzyme mimetic activities. However, the complete pharmacological potential of nanoceria needs to be explored yet. In this work, antioxidant and cytoprotective potentials of nanoceria against H2O2 induced oxidative stress was examined both in fibroblast cells and in zebrafish. Furthermore, the cellular uptake, cell cycle, mitochondrial membrane potential, morphological and nuclear analysis suggests that the nanoceria successfully defend the cells against oxidative stress induced cell death. Thus, the present study opens up new avenue of nanoceria for future biomedical applications.

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Synthesis of gold nanoparticles and nanoclusters in a supramolecular gel and their applications in catalytic reduction of p-nitrophenol to p-aminophenol and Hg(ii) sensing

Abstract: Seven gelator molecules giving supramolecular gels produced Au-nanoparticles and fluorescent, small Au-nanoclusters. Such Au-nanoparticle containing gels catalyzed the reduction of p-nitrophenol to p-aminophenol without NaBH4. The fluorescent Au-nanoclusters acted as a Hg(ii) sensor.

Cited by 22 publications

References 92 publications

Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification

Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification

An Insight into Nitromethane as an Organic Nitrile Alternative Source towards the Synthesis of Aryl Nitriles

Therapeutic Nanozyme: Antioxidative and cytoprotective effects of nanoceria against hydrogen peroxide induced oxidative stress in fibroblast cells and in zebrafish

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