Synthesis of heterocyclic scaffolds through 6-aminouracil-involved multicomponent reactions

Abstract

There is a wide range of multicomponent reactions that include 6-aminouracil in the synthesis of heterocyclic compounds. This review highlights the advances in the use of 6-aminouracil in the synthesis of various organic compounds.

N-(Pyrazol-5-yl)cyanoacetamide in heterocyclic synthesis: synthesis of novel N-(pyrazol-5-yl)pyridine-3,5-dicarbonitrile, pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-7-carbonitrile and pyrazolo[4,3-e]pyrido[1,2-a]pyrimidine-6,8-dicarbonitrile moieties

“…Route B involves the initial addition of the amino group of the enamine 5 to the β-carbon of the activated double bond of 6 followed by cyclization affected by β-carbon of the enamine 5 to form 6-amino-8-aryl-pyrazolo [1,5-a]pyrido[3,2-e]pyrimidine-7-carbonitrile 8. Route A was approved based on literature similarities 29,30 (cf. scheme 3).…”

Visible-Light-Induced Domino Cyclization to Access Pyri-do[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction

“…[2,3] With the aim for seeking more readily available substrates, and facile operational processes, as well as more structural diversity of pyrido[2, 3-d ]pyrimidine-2,4-diones, many attempts toward multicomponent cascade cyclization from 6-aminouraciles with easily available aldehydes/ketones and alkyl nitriles or ketones, have been accomplished (Scheme 1a-II). [4,5] Despite these outstanding works, the exploration of conceptually distinct strategies, especially avoiding harsh reaction conditions such as high temperature, excessive additives, long reaction times as well as limited substrate scope, is obviously yet an urgent issue.…”

Recent advances in the application of magnetic bio-polymers as catalysts in multicomponent reactions

“…Hence, the design and application of MCRs for the synthesis of organic compounds are highly important. 45–50…”