Synthesis of indazoloquinazoline system (microreview)

Roopan, Selvaraj Mohana; Palaniraja, Jeyakannu

doi:10.1007/s10593-016-1838-2

Cited by 7 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Heterocyclic compounds are cyclic compounds in which another atom replaces one or more carbons in the ring (Ram et al 2019 ). Thus, the compounds comprising heteroatoms like nitrogen, oxygen, sulfur, phosphorous, silicon, boron, and the like make the heterocyclic compounds one of the most prevalent classes of organic compounds (Roopan and Palaniraja 2016 ). They are persistent in biology and do play an integral function in medicinal chemistry, particularly in drug design and synthesis.…”

Section: Introductionmentioning

confidence: 99%

Biological activity of oxadiazole and thiadiazole derivatives

Atmaram

Roopan

2022

Appl Microbiol Biotechnol

Self Cite

View full text Add to dashboard Cite

The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-known heterocycles, being a common and essential feature of a variety of natural products and medicinal agents. These scaffolds take up the center position and are the core structural components of numerous drugs that belong to different categories. These include antimicrobial, anti-tubercular, anti-inflammatory, analgesic, antiepileptic, antiviral, and anticancer agents. In this review, we mostly talk about the isomers 1,2,4-oxadiazole and 1,3,4-thiadiazole because they have important pharmacological properties. This is partly because they are chemical and heat resistant, unlike other isomers, and they can be used as bio-isosteric replacements in drug design. We are reviewing the structural modifications of different oxadiazole and thiadiazole derivatives, more specifically, the anti-tubercular and anticancer pharmacological activities reported over the last 5 years, as we have undertaken this as a core area of research. This review article desires to do a thorough study and analysis of the recent progress made in the important biological isomers 1,2,4-oxadiazole and 1,3,4-thiadiazol. This will be a great place to start for future research. Key points • Five-membered heterocyclic compound chemistry and biological activity recent survey. • Synthesis and pharmacological evolution of 1,2,4-oxadiazole and 1,3,4-thiadiazole are discussed in detail. • The value and significance of heterocyclic compounds in the field of drug designing are highlighted. Supplementary Information The online version contains supplementary material available at 10.1007/s00253-022-11969-0.

show abstract

Section: Introductionmentioning

confidence: 99%

Biological activity of oxadiazole and thiadiazole derivatives

Atmaram

Roopan

2022

Appl Microbiol Biotechnol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Indazoloquinazolines, containing indazole and quinazoline moieties, are ubiquitous skeletons in biological molecules, fluorescence materials as well as dyes. 1 In particular, indazolo[2,3- a ]quinazoline analogues possess prominent biological properties, such as antifungal, antibacterial and anti-inflammatory properties (Scheme 1a). 2 Unfortunately, despite their significant utility, little attention has been paid to constructing indazolo[2,3- a ]quinazoline frameworks.…”

mentioning

confidence: 99%