Synthesis of Iridium(III) Complex Bearing 1-Thio-β-D-glucose Tetraacetate Moieties and its Photogeneration of Singlet Oxygen

Abstract

Investigation of effective photodynamic therapy (PDT) reagents needs to observe 1 O 2 . The observation of the amount of photogenerated 1 O 2 emission at 1,270 nm is one of the engaged method for 1 O 2 generation evolution quantitatively, however it is convenient to observe fluorescent spectra relevant to a phosphorescence of singlet molecular oxygen due to the energy transfer from PDT reagents to 3 O 2 . Ir(III) complex containing a thioglucose tetraacetate-conjugated bipyridyl ligand were synthesized newly, and the photogeneration of 1 O 2 was confirmed by measurement of a phosphorescence of singlet molecular oxygen.