Chlorin e6 is a heterocycle exhibiting spectral absorption in the 600-700 nm wavelength range used for photodynamic therapy (PDT). Herein, a sugar-conjugated chlorin e6 derivative was synthesized on a large scale. An alkyl spacer was fabricated by controlling the alkoxylation conditions between the thio-sugar and chlorin e6 and thio-glucose-conjugated chlorin e6 was successfully synthesized.Heterocycles such as porphyrins and chlorins show great potential to be developed as new drugs.Therefore, it is important to develop new synthesis methods and pathways for drugs to fight novel

Investigation of effective photodynamic therapy (PDT) reagents needs to observe 1 O 2 . The observation of the amount of photogenerated 1 O 2 emission at 1,270 nm is one of the engaged method for 1 O 2 generation evolution quantitatively, however it is convenient to observe fluorescent spectra relevant to a phosphorescence of singlet molecular oxygen due to the energy transfer from PDT reagents to 3 O 2 . Ir(III) complex containing a thioglucose tetraacetate-conjugated bipyridyl ligand were synthesized newly, and the photogeneration of 1 O 2 was confirmed by measurement of a phosphorescence of singlet molecular oxygen.