2017
DOI: 10.2147/ijn.s133009
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Synthesis of magnetic molecularly imprinted polymers with excellent biocompatibility for the selective separation and inhibition of testosterone in prostate cancer cells

Abstract: Purpose Androgen plays an important role in the progression of prostate cancer. In the present study, novel magnetic molecularly imprinted polymers (MMIPs) with good biocompatibility were produced for the selective separation and inhibition of testosterone in prostate cancer cells. Materials and methods MMIPs were prepared by using magnetic nanospheres, gelatin, and testosterone as the supporting materials, functional monomer, and the template molecule, respectively. Th… Show more

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Cited by 27 publications
(13 citation statements)
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“…The high ROS level naturally triggered apoptosis of most tumor cells. [54] A similar example was reported by Tang et al [55] Testosterone (TSTO)-imprinted nanoMIPs were developed to block the TSTO-androgen receptor (AR) pathway. These nanoMIPs specifically absorbed intracellular testosterone and then inhibited the cascade of TSTO-AR pathway related functions as well as the growth of androgen-dependent prostate cancer cells through suppression of the cell cycle progression.…”
Section: Antitumor Efficacymentioning
confidence: 67%
“…The high ROS level naturally triggered apoptosis of most tumor cells. [54] A similar example was reported by Tang et al [55] Testosterone (TSTO)-imprinted nanoMIPs were developed to block the TSTO-androgen receptor (AR) pathway. These nanoMIPs specifically absorbed intracellular testosterone and then inhibited the cascade of TSTO-AR pathway related functions as well as the growth of androgen-dependent prostate cancer cells through suppression of the cell cycle progression.…”
Section: Antitumor Efficacymentioning
confidence: 67%
“…Shea et al synthesized a polymer NP that can bind vascular epidermal growth factor (VEGF) and thereby suppress tumor growth through reducing blood‐vessel formation . Furthermore, Guo et al reported molecularly imprinted NPs that can bind testosterone and thus block the testosterone–androgen receptor pathway in prostate cancer . Molecularly imprinted polymers (MIPs), synthesized through polymerization in the presence of a template, exhibit affinity and specificity to the template .…”
Section: Methodsmentioning
confidence: 99%
“…38 Due to the lack of sound theoretical guidance for rational design and controllable fabrication, however, the development of enzyme-mimicking MIPs has still largely lagged behind their counterpart, antibody-mimicking MIPs, which have already found applications in many important areas, such as affinity separation, 39,40 disease diagnosis, 41–43 drug delivery, 44–46 targeted bioimaging, 47 and cancer therapy. 48–51…”
Section: Introductionmentioning
confidence: 99%