Synthesis of N-(2-hydroxypr opyl) methacrylamide copolymers with antimicrobial activity

Solovsky, Mikhail V.; Ulbrich, Karel; Kopeček, Jindřich

doi:10.1016/0142-9612(83)90069-8

Cited by 43 publications

(10 citation statements)

References 14 publications

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“…Because the amount of available drug is limited and there is no release of drug from the device into the adjacent fluid or tissue, the antimicrobial properties of covalently attached agents are limited. Although the authors claimed antimicrobial efficacy by antiadhesive and antiproliferative action of these hybrids [36][37][38] , no in vivo studies have yet demonstrated an antibacterial effect.…”

Section: Covalent Bonding Of Anti-infective Substancesmentioning

confidence: 93%

Novel Strategies to Prevent Catheter-Associated Infections in Oncology Patients

Schierholz¹,

Beuth²,

Rump³

et al. 2001

Journal of Chemotherapy

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Aggressive cytotoxic treatment of cancer contributes to the growing number of life-threatening infections. Vascular catheters create predominant risks for staphylococcal, enterococcal and candida blood stream infections. Although the contaminating microorganisms may be few in number, the altered host immune response in the presence of such implants as well as disease-associated immunosuppression implies that even small bacterial counts have to be regarded as highly virulent species. Diagnosis of catheter-related infection (CRI) remains difficult before withdrawal of the suspected catheter. Positive culture of catheter surface, lumen and hub and positive peripheral blood probes (paired quantitative blood culture) are predictive for catheter related bacteremia (CRB). Diligent catheter care and effective antimicrobial catheters may reduce prolonged hospital stay, increased morbidity or mortality and serious economical consequences. The most promising approach features the incorporation of antimicrobial drugs into the polymer matrices that entrap but do not bind the drugs, allowing for extended release. For the efficacious prevention of colonization in the microenvironment of the implantable device the concentration of the antimicrobial substances must exceed usual antibiotic concentrations by a thousand-fold. This is the desired effect--high concentration near the device surface and very low systemic concentration. Incorporation of antimicrobials in the bulk material that constitutes a device can be effective as shown in several in vitro and in vivo studies. In the future, modification of both short-term and long-term catheters by biofilm-active antimicrobials creating slow delivery systems may provide an effective method to protect patients from nosocomial infection in oncology.

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Section: Covalent Bonding Of Anti-infective Substancesmentioning

confidence: 93%

Novel Strategies to Prevent Catheter-Associated Infections in Oncology Patients

Schierholz¹,

Beuth²,

Rump³

et al. 2001

Journal of Chemotherapy

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“…The HPMA copolymer with GFLG side chains is made by polymerization of HPMA and methacryloyl-GFLG-nitrophenyl ester monomers, and the drug is conjugated by aminolysis [186,189,192]. Drugs studied have included doxorubicin [185], insulin [193], and ampicillin [190]. The peptide sequence was selected because it is cleavable by cathepsin B, releasing the drug payload into the lysosomal compartment of the target cell, but other peptides could of course be used to target various other enzymes and thus other cell types or compartments of the body using this same basic system.…”

Section: Chemically-responsive Hydrogelsmentioning

confidence: 99%

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Koetting

Peters

Steichen

et al. 2015

Materials Science and Engineering: R: Reports

923

688

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Over the past century, hydrogels have emerged as effective materials for an immense variety of applications. The unique network structure of hydrogels enables very high levels of hydrophilicity and biocompatibility, while at the same time exhibiting the soft physical properties associated with living tissue, making them ideal biomaterials. Stimulus-responsive hydrogels have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. This enhanced control has enabled groundbreaking advances in healthcare, allowing for more effective treatment of a vast array of diseases and improved approaches for tissue engineering and wound healing. In this extensive review, we identify and discuss the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels. We discuss the theoretical analysis of hydrogel properties and the mechanisms used to create these responses, highlighting both the pioneering and most recent work in all of these fields. Finally, we review the many current and proposed applications of these hydrogels in medicine and industry.

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“…Copolymerization of HPMA with a polymerizable derivative of a drug, e.g., N -(4-aminobenzensulfonyl)- N ′-butylurea [27] is the example of the first route. Insulin [28], chymotrypsin [29,30] and ampicillin [31] (Fig. 2) were attached to HPMA copolymers by aminolysis [32,33] of reactive polymeric precursors.…”

Section: Originsmentioning

confidence: 99%

HPMA copolymers: Origins, early developments, present, and future☆

Kopeček

Kopečková

2010

Advanced Drug Delivery Reviews

535

428

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The overview covers the discovery of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, initial studies on their synthesis, evaluation of biological properties, and explorations of their potential as carriers of biologically active compounds in general and anticancer drugs in particular. The focus is on the research in the authors' laboratory -the development of macromolecular therapeutics for the treatment of cancer and musculoskeletal diseases. In addition, the evaluation of HPMA (co)polymers as building blocks of mod and new biomaterials is presented: the utilization of semitelechelic poly(HPMA) and HPMA copolymers for the modification of biomaterial and protein surfaces and the design of hybrid block and graft HPMA copolymers that self-assemble into smart hydrogels. Finally, suggestions for the design of second-generation macromolecular therapeutics are portrayed.

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Synthesis of N-(2-hydroxypr opyl) methacrylamide copolymers with antimicrobial activity

Cited by 43 publications

References 14 publications

Novel Strategies to Prevent Catheter-Associated Infections in Oncology Patients

Novel Strategies to Prevent Catheter-Associated Infections in Oncology Patients

Stimulus-responsive hydrogels: Theory, modern advances, and applications

HPMA copolymers: Origins, early developments, present, and future☆

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