Synthesis of new nicotinic acid hydrazide metal complexes: Potential anti-cancer drug, supramolecular architecture, antibacterial studies and catalytic properties.

Ashma,; Yahya, Showket; Subramani, A.; Tamilarasan, R.; Sasikumar, G.; Askarali, S.J.; Al‐Lohedan, Hamad A.; Muthusamy, Karnan

doi:10.1016/j.molstruc.2021.131860

Cited by 14 publications

(14 citation statements)

References 27 publications

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“…The ligand spectrum reveals multiple signals at δ (3.44–3.60 ppm), assignable to −CH 2 protons. [ 56,57 ] These signals undergo shift to δ (3.28–4.06 ppm) in Cd(II) complex. The ligand −NH 2 and −NH protons signals locate at δ (4.23 and 9.12 ppm), respectively.…”

Section: Resultsmentioning

confidence: 99%

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Spectral studies, thermal investigations, and anticancer activity of some divalent metal complexes derived from 2‐(4‐bromophenylamino)acetohydrazide ligand

Emara

El‐Sayed

Khalaf‐Allah

et al. 2022

Applied Organom Chemis

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A series of biologically active metal complexes was yielded from the reactions of 2‐(4‐bromophenylamino)acetohydrazide ligand (HL) with Co(II), Ni(II), Cu(II), Cd(II) chlorides, CuBr2, Cu(CH3COO)2, and Cu(ClO4)2 salts. The structure and stereochemistry of the afforded complexes were elucidated by means of elemental analyses, molar conductance, magnetic susceptibility, thermal analyses (TG/DTG), and spectral techniques (mass, IR, UV‐Vis, and 1H NMR). Elemental analyses along with molar conductance data demonstrated that all metal complexes are nonelectrolyte and were formed with 1L:1M, 1L:2M, and 2L:1M stoichiometry. IR spectral data provided an evidence for the neutral bidentate behavior of the hydrazide ligand toward metal ions via carbonyl oxygen and amino nitrogen atoms (ON donor). Magnetic susceptibility along with electronic absorption spectral results authenticated that all complexes have an octahedral geometry except, CuCl2 complex (3), which possessed a square planar one. The hydrazide ligand and some of its synthesized metal complexes were screened in vitro for their antitumor and apoptotic activity. The results showed that CuBr2 complex (4) has promising anticancer activities against breast MCF7, liver HepG2, and colorectal HCT 116 cancerous cells through induction of proapoptotic gene (Bax) and inhibit the antiapoptotic gene (Bcl‐2), thus increase the Bax/Bcl‐2 ratio. Moreover, these newly synthesized compounds were most potent and can be used as a therapeutic chemoprevention against these cancerous cells compared with doxorubicin (DOX), the currently available anticancer drug against solid tumors.

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Section: Resultsmentioning

confidence: 99%

“…The ligand spectrum reveals multiple signals at δ (3.44-3.60 ppm), assignable to ÀCH 2 protons. [56,57] ÀNH protons signals locate at δ (4.23 and 9.12 ppm), respectively. [31,58,59] These two signals shifted to δ (4.51 and 9.36 ppm) in Cd(II) complex, confirming the participation of NH 2 in chelation.…”

Section: H 1 Nmr Spectral Investigationmentioning

confidence: 99%

Spectral studies, thermal investigations, and anticancer activity of some divalent metal complexes derived from 2‐(4‐bromophenylamino)acetohydrazide ligand

Emara

El‐Sayed

Khalaf‐Allah

et al. 2022

Applied Organom Chemis

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“…On the other hand, in 2022, Ashma et al [ 142 ] focused their attention on the synthesis of nicotinic acid hydrazide metal complexes and their potential anticancer and antibacterial activity, together with their ability to act as a catalyst. This work addressed newer bidentate Schiff bases, such as L5 and L6, and their metal complexes Co(II), Ni(II), Cu(II) and Zn(II) were synthesized by a one-pot method.…”

Section: Anticancer Compounds Obtained From Mcrs Approachesmentioning

confidence: 99%

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

Graziano

Stefanachi

Contino

et al. 2023

IJMS

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Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and development. MCRs are flexible transformations in which three or more substrates react to form structurally complex products with high atomic efficiency. They are being increasingly appreciated as a highly exploratory and evolutionary tool by the medicinal chemistry community, opening the door to more sustainable, cost-effective and rapid synthesis of biologically active molecules. In recent years, MCR-based synthetic strategies have found extensive application in the field of drug discovery, and several anticancer drugs have been synthesized through MCRs. In this review, we present an overview of representative and recent literature examples documenting different approaches and applications of MCRs in the development of new anticancer drugs.

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“…After incubating the cells for 21-24 h, the cells attached to the surface and attained normal morphology. The cells were then used for further experiments (Ashma et al, 2022).…”

Section: Cell Culturementioning

confidence: 99%

In vitro evaluation of antimicrobial and anticancer potential of Artemisia absinthium growing in Kashmir Himalayas

Sofi

Nanda

Sofi

et al. 2022

JANS

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Herbal medicines are an important and growing part of International pharmacopeia. Research and testing enhance our understanding of their medical properties, making them a safer alternative or preferable option to allopathic medication. Plant-derived pharmaceuticals are gaining popularity due to the belief that "green medicine" is safer and more trustworthy than expensive synthetic drugs. This study aimed to evaluate the antimicrobial and anticancer potential of the methanolic leaf extract of Artemisia absinthium against human lung cancer A549 cell line by well diffusion method and MTT assay, respectively. The A. absinthium leaf extract showed the highest activity against Enterococcus faecalis (20 ± 0.7 mm), and Escherichia coli (18 ± 0.8 mm), followed by Pseudomonas aeruginosa (16 ± 0.6 mm), Candida albicans (14 ± 0.9 mm) and Staphylococcus aureus (13 ± 0.8 mm), with MIC values 128, 128, 128, 256 and 256 µg/mL respectively. The methanolic extract of A. absinthium showed significant (p ≤ 0.05) cytotoxicity against the A549 cancer cell line with an IC50 value of 36.8 µg/mL. The present study's findings give strong evidence for using the methanolic leaf extract of A. absinthium as an effective ethnomedicinal agent and a possible candidate for treating various human diseases and a potent bioactive agent in anticancer medications.

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Synthesis of new nicotinic acid hydrazide metal complexes: Potential anti-cancer drug, supramolecular architecture, antibacterial studies and catalytic properties.

Cited by 14 publications

References 27 publications

Spectral studies, thermal investigations, and anticancer activity of some divalent metal complexes derived from 2‐(4‐bromophenylamino)acetohydrazide ligand

Spectral studies, thermal investigations, and anticancer activity of some divalent metal complexes derived from 2‐(4‐bromophenylamino)acetohydrazide ligand

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

In vitro evaluation of antimicrobial and anticancer potential of Artemisia absinthium growing in Kashmir Himalayas

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