2020
DOI: 10.1016/j.bmcl.2019.126760
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Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells

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Cited by 16 publications
(5 citation statements)
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“…Because TSP50-induced cell proliferation and tumorigenesis are dependent on the activation of the NF- k B signaling pathway [ 78 ], it has been suggested that the antiproliferative effect of cardamonin could be related to the inhibition of TSP50/NF-κB protein expression [ 79 ]. Furthermore, the ability to suppress cancer proliferation via the inhibition of NF-κB signaling has also been reported in several other chalcones, such as 4-Boc-piperidone chalcones [ 80 ], bichalcone analogs [ 81 ], IBC [ 82 ], hydroxysafflor yellow A [ 83 ] and butein [ 84 ].…”
Section: Molecular and Cellular Mechanisms Of Actionmentioning
confidence: 98%
“…Because TSP50-induced cell proliferation and tumorigenesis are dependent on the activation of the NF- k B signaling pathway [ 78 ], it has been suggested that the antiproliferative effect of cardamonin could be related to the inhibition of TSP50/NF-κB protein expression [ 79 ]. Furthermore, the ability to suppress cancer proliferation via the inhibition of NF-κB signaling has also been reported in several other chalcones, such as 4-Boc-piperidone chalcones [ 80 ], bichalcone analogs [ 81 ], IBC [ 82 ], hydroxysafflor yellow A [ 83 ] and butein [ 84 ].…”
Section: Molecular and Cellular Mechanisms Of Actionmentioning
confidence: 98%
“…Finally, 173 of the 219 articles relating to CURC and PCa reported data outcomes on the mechanistic pathways (Supplemental Table 3), which we used to perform descriptive and qualitative analysis. 7,12,13,15…”
Section: Resultsmentioning
confidence: 99%
“…Particularly, thiopyrans have shown important biological properties such as analgesic, [2] anti‐cancer, [3] anti‐hyperplasia, [4] antibacterial, [5] among others [6] (Figure 1 a). Meanwhile, piperidones have been demonstrated to be important therapeutic agents against different diseases such as Alzheimer disease [7] anti‐cancer [8] and inflammatory bowel disease (IBD) [9] (Figure 1 b). The constant demand of these significant scaffolds has driven the development of new synthetic methods, which have contributed to the diversification of these skeletons [10] .…”
Section: Figurementioning
confidence: 99%