Synthesis of novel tanshinone derivatives for treatment of castration‐resistant prostate cancer

Xu, Defeng; Hu, Hang; Guan, Jing; Jiang, Da; Xie, Yipeng; Liu, Yalin; Kong, Ren; Song, Guoqiang; Zhou, Huan

doi:10.1111/cbdd.13567

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…Tanshinone capsules can treat FSD through the following mechanism. Firstly, tanshinone has an anti-androgen effect and estrogen activity, which can regulate skin endocrine and metabolic function, and maintain hormone balance (39,40). Secondly, tanshinone capsules have a broad-spectrum antibacterial effects, such as hydroxytanshinone and methyl tanshinate can kill and inhibit a variety of aerobic and anaerobic bacteria, especially can inhibit gram-positive bacteria (41,42).…”

Section: Discussionmentioning

confidence: 99%

Tanshinone Capsules Combined With Prednisone for Facial Seborrheic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Huang

Tang

et al. 2022

Front. Med.

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BackgroundFacial seborrheic dermatitis (FSD), also called facial seborrheic eczema, is a common disease affecting both male and female patients worldwide. Tanshinone is the main bioactive component extracted from the Traditional Chinese Medicine Salvia miltiorrhiza Bunge, which is widely used in treating skin inflammatory diseases. It is necessary to evaluate the clinical evidence for tanshinone capsule treatment of FSD. This study aimed to evaluate the safety and effectiveness of tanshinone capsules combined with prednisone in the treatment of facial seborrheic dermatitis and to provide evidence for clinical practice.MethodsStudies were searched in PubMed, the Cochrane Library, the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, the Chinese Scientific Journal Database, and WanFang Database before October 2021. We also searched for randomized controlled clinical trials (RCT) of tanshinone capsules combined with prednisone on facial seborrheic dermatitis. The meta-analysis was conducted according to the guidelines of the Cochrane Handbook. Two reviewers regulated the research selection, data extraction, and risk of bias assessment, respectively, and a third reviewer was used for consulting when necessary. Review Manager Software 5.3 was used for meta-analysis.ResultsA total of 10 RCTs with 916 participants were included. Nine studies reported total effectiveness, five studies reported symptom score, seven studies reported adverse events, and four studies reported recurrence rate. The duration of treatment was 4 to 8 weeks. Combination therapy showed better clinical effects compared to the prednisone (OR: 5.82; 95% CI: 3.53, 9.59; p < 0.00001). Combination therapy could repair skin lesions (MD: −0.40; 95% CI: −0.51, −0.30; p < 0.00001), reduce skin erythema (MD: −0.58, 95% CI: −0.67, −0.49; p < 0.00001), relieve skin itch (MD: −0.70; 95% CI −0.77, −0.63; p < 0.00001), and desquamation score (MD: −0.64; 95% CI: −0.71, −0.56; p < 0.00001). Furthermore, combination therapy could reduce adverse events (OR: 0.46; 95% CI: 0.26, 0.84; p = 0.01) and control recurrence rate (OR: 0.22; 95% CI: 0.13, 0.36; p < 0.00001).ConclusionsCompared with prednisone, tanshinone capsules combined with prednisone may be effective in the treatment of facial seborrheic dermatitis. However, due to the high risk and ambiguity of bias in the included trials, the conclusion of this study must be interpreted carefully.

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Section: Discussionmentioning

confidence: 99%

Tanshinone Capsules Combined With Prednisone for Facial Seborrheic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Huang

Tang

et al. 2022

Front. Med.

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“…毕跃峰等 [9] 为改善丹参酮 IIA 的水溶性, 运用孪药设计原理, 将丹参水溶性酚酸类结构通过酯键引入 A 秦洪波等 [10] 胞的生长起着重要作用, 雄激素受体是治疗前列腺癌的主要靶点. 徐德峰等 [11] 以丹参酮 IIA 为原料, 在乙酸/乙酸铵反应体系中与取代苯甲醛进行 Debus-Radziszewski 多种致癌基因(如 c-myc、K-ras、Bcl-2 等)在转移性三阴乳腺癌(TNBC)中过表达, 致癌基因启动子中存在大量富含鸟嘌呤的序列, 在生理条件下可形成 G-四联体(G4)结构, 使其成为潜在的癌症治疗靶点 [12a-12b] . Vilar…”

Section: A 环结构优化unclassified

Research Progress on Structural Optimization on the Lipid-Soluble Ingredients of Salvia miltiorrhiza

Li¹,

Wang²,

Liu³

2023

Chinese Journal of Organic Chemistry

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As a traditional Chinese medicine, Salvia miltiorrhiza has been widely applied in the treatment of cardiovascular diseases in clinical. Research on its active components and derivatives has become an issue of great focus both domestically and internationally. The active ingredients of Salvia miltiorrhiza are mainly divided into lipid-soluble and water-soluble ingredients with the lipid-soluble ones performing various pharmacological properties. However, their poor solubility and bioavailability have limited their clinical applications. In order to promote the clinical application of lipid-soluble ingredients of Salvia miltiorrhiza, these components are used as lead compounds to perform structural optimization to improve drug-like properties. In order to generate novel research ideas for the development of novel drugs based on lipid-soluble ingredients of Salvia miltiorrhiza, the research progress of structural optimization and related biological activities of the major lipid-soluble ingredients of Salvia miltiorrhiza in recent years is reviewed, the structural optimization strategy of the drug-like properties of these compounds and the synthetic approaches of their derivatives are summarized, and the effects of different structure modifications on pharmacological activities are described.

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“…However, after 18 months of treatment, the majority of the patients relapsed subsequently, an initial response to ADT, and acquired CRPC. Therefore, there is an urgent need to discover more efficacious AR-suppressing agents for the treatment of CRPC (Xu et al, 2019).…”

Section: Natural Therapeutic Products For Castration-resistant Prostate Cancer Treatment and Managementmentioning

confidence: 99%

Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies

Singla

Sai

Chopra

et al. 2021

Front. Cell Dev. Biol.

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Prostate cancer is the most common type of cancer among men and the second most frequent cause of cancer-related mortality around the world. The progression of advanced prostate cancer to castration-resistant prostate cancer (CRPC) plays a major role in disease-associated morbidity and mortality, posing a significant therapeutic challenge. Resistance has been associated with the activation of androgen receptors via several mechanisms, including alternative dehydroepiandrosterone biosynthetic pathways, other androgen receptor activator molecules, oncogenes, and carcinogenic signaling pathways. Tumor microenvironment plays a critical role not only in the cancer progression but also in the drug resistance. Numerous natural products have shown major potential against particular or multiple resistance pathways as shown by in vitro and in vivo studies. However, their efficacy in clinical trials has been undermined by their unfavorable pharmacological properties (hydrophobic molecules, instability, low pharmacokinetic profile, poor water solubility, and high excretion rate). Nanoparticle formulations can provide a way out of the stalemate, employing targeted drug delivery, improved pharmacokinetic drug profile, and transportation of diagnostic and therapeutic agents via otherwise impermeable biological barriers. This review compiles the available evidence regarding the use of natural products for the management of CRPC with a focus on nanoparticle formulations. PubMed and Google Scholar search engines were used for preclinical studies, while ClinicalTrials.gov and PubMed were searched for clinical studies. The results of our study suggest the efficacy of natural compounds such as curcumin, resveratrol, apigenin, quercetin, fisetin, luteolin, kaempferol, genistein, berberine, ursolic acid, eugenol, gingerol, and ellagic acid against several mechanisms leading to castration resistance in preclinical studies, but fail to set the disease under control in clinical studies. Nanoparticle formulations of curcumin and quercetin seem to increase their potential in clinical settings. Using nanoparticles based on betulinic acid, capsaicin, sintokamide A, niphatenones A and B, as well as atraric acid seems promising but needs to be verified with preclinical and clinical studies.

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Synthesis of novel tanshinone derivatives for treatment of castration‐resistant prostate cancer

Cited by 12 publications

References 28 publications

Tanshinone Capsules Combined With Prednisone for Facial Seborrheic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Tanshinone Capsules Combined With Prednisone for Facial Seborrheic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Research Progress on Structural Optimization on the Lipid-Soluble Ingredients of Salvia miltiorrhiza

Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies

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