Synthesis of ordered mesoporous silica templated with biocompatible surfactants and applications in controlled release of drugs

Botella, Pablo; Corma, Avelino; Quesada, Manuel

doi:10.1039/c2jm16291a

Cited by 45 publications

(33 citation statements)

References 42 publications

(64 reference statements)

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“…55,56 Moreover, the loading capacity and loading time of MS@NH 2 @COOH have signi¯cant advantages over previously reported drug delivery systems (see Table 4). [35][36][37][38] @COOH@x under a physiological environment and weak acid conditions. The DOX showed a pH-sensitive and sustained drug release from the modi¯ed silica nanorattle up to two days, with a more rapid drug release rate at pH 5.5 (close to the pH in lysosomes) than at pH 7.4 (the pH of blood plasma).…”

Section: -9mentioning

confidence: 99%

“…Although these organic functional groups can ensure the good adsorption of drugs, such as common model drugs aspirin 32,33 and DOX, 34 their loading capacity is low and the loading takes a long time. [35][36][37][38] For instance, Feng et al 34 developed a targeted anticancer drug delivery system based on folate-conjugated nanospheres modied with boron nitride (BNNS-FA). However, the DOX loading capacity of the BNNS and BNNS-FA complexes was calculated only to be 6.9 g and 20.7 g per 1 mg of carriers, respectively, which is lower than ours.…”

Section: Introductionmentioning

confidence: 99%

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Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery

Wang

Zhang

et al. 2019

NANO

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Mesoporous silica (MS) spheres of different sizes with pH-responsive characteristics were synthesized based on Stöber’s theory. Organic functionalization with aminopropyl and carboxyl groups resulted in different materials, namely, MS@NH2@COOH. MS@NH2@COOH were observed to have a large number of carboxyl groups and multiamine chains, and were grafted into pore channels and pore outlets through systematic characterization analyses. All modified samples demonstrated the controlling of the delivery rate of DOX from the siliceous matrix. We also compared the drug release behavior of the DOX-loaded materials at high pH (7.4) and low pH (5.5) and studied the cytotoxicity on A549 cells. The experimental results indicated that the drug delivery system can better control drug release and have potential applications in the drug delivery field.

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Section: -9mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery

Wang

Zhang

et al. 2019

NANO

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“…[1][2][3][4][5][6] In this approach, surfactant micelles serve as both a structure directing agent and a suitable environment for the entrapment of a wide-range of hydrophobic and hydrophilic molecules. [1][2][3][4][5][6] In this approach, surfactant micelles serve as both a structure directing agent and a suitable environment for the entrapment of a wide-range of hydrophobic and hydrophilic molecules.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of multifunctional surfactant containing capped mesoporous silica nanoparticles

et al. 2016

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† Electronic supplementary information (ESI) available. A PDF containing additional figures and a table. This paper reports the synthesis of silica capped surfactant (CTAB) and dye (Rose Bengal; RB) containing mesoporous silica nanoparticles (MSNs). Capping the pores of surfactant containing MSNs with a thin silica layer decreased the immediate surfactant originated cytotoxicity of these particles without affecting their long term (3 days) cytotoxicity. Also, silica capping process almost completely prevented the hemolytic activity of the surfactant containing MSNs. In addition, improved uptake of silica capped MSNs compared to the uncapped particles by cancer cells was demonstrated. The delayed cytotoxicity, low hemolytic activity, and better cellular uptake of silica capped MSNs make them promising for the development of safe (i. e. with fewer side effects) yet efficient theranostic agents. These nanocarriers may release the loaded cytotoxic molecules (CTAB) mostly after being 2 accumulated in the tumor site and cause minimal damage to the normal tissues and blood components. In addition, the nanoscale confinement of RB molecules inside the pores of MSNs makes the particles brightly fluorescent. Furthermore, it was demonstrated that due to the singlet oxygen generation capability of the RB dye the silica capped MSNs can be used also for photodynamic therapy of cancer. 19 and (ii) improve the cellular uptake. We believe that the preliminary results obtained in this study show the promising potential of capped surfactant containing multifunctional MSNs in biomedical applications. Future studies may include surface modification of silica capped surfactant containing MSNs with antifouling polymers and targeting agents and their in vivo verification. Experimental Section Materials Cetyltriammoniumbromide (CTAB), F127 pluronic polymer, 3-(Trihydroxysilyl) propyl methylphosphonate (TSPMP), Rose Bengal, 3-(4,5-dimethyl-2-thiazolyl)-2,5diphenyltetrazolium bromide (MTT), and 1,3-Diphenylisobenzofuran were purchased from Sigma Aldrich (USA). Tetraethyl orthosilicate (TEOS) and Methyltrimethoxysilane (MTMS)were purchased from Merck (Germany). All chemicals were used as received. Preparation of surfactant containing MSNsMSNs were prepared by modifying previous reports. 15,[40][41][42] To synthesize rMSN, 200 mg CTAB and 10 mg of F127 were dissolved in 95 mL of water and 0.8 mL of RB solution in water (5 mg/mL) and 0.7 mL of NaOH (2 M) were added to this solution. Then the reaction mixture was heated to 80 °C while stirring vigorously (600 rpm). After temperature fixed at 80 °C, 1 mL of TEOS was rapidly added to the reaction mixture. After 15 min, 60 µL of MTMS and after 45 min, 250 µL of TSPMP was added dropwise and reaction mixture was further stirred for 90 min. Finally, particles were collected by centrifugation at 9000 rpm for 20 min and washed with water twice. To synthesize rMSN-ts, 1 mL of TEOS was added dropwise to the reaction mixture 20 min before the TSPMP addition. Other parameters were same with the rMSN synthe...

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“…Mesoporous silica has many Si-OH surface groups that can be functionalized via silane coupling agents [22]: amino, thiol, and cyano. These functional groups offer good adsorption of drugs such as aspirin [23,24] and ibuprofen [25], but their load capacity is not high and requires a longer time [23,24,26,27]. Casasús et al [28] used a polyamine chain of silane coupling agents on the surface of mesoporous silica.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release

Song

Guo

et al. 2018

Journal of Nanomaterials

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Mesoporous silica spheres were synthesized by using Stöber theory . Calcination of the mesostructured phase resulted in the starting solid. Organic modification with aminopropyl groups resulted in two MSN-40 materials: named MSN-NH 2 and MSN-DQ-40, respectively. These two kinds of samples with different pore sizes (obtained from 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethox-ysilane (NQ-62) and modified NQ-62) showed control of the delivery rate of ibuprofen (IBU) from the siliceous matrix. The obtained sample from modified NQ-62 has an increased loading rate and shows better control of the delivery rate of IBU than the obtained sample from NQ-62. These three solids were characterized using standard solid state procedures. During tests of in vitro drug release, an interesting phenomenon was observed: at high pH (pH 7.45), IBU in all carriers was released slowly; at low pH (pH 4.5), only a part of the IBU was slowly released from this carrier within 25 hours; most IBU was effectively confined in mesoporous material, but the remaining IBU was released rapidly and completely after 25 hours.

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Synthesis of ordered mesoporous silica templated with biocompatible surfactants and applications in controlled release of drugs

Cited by 45 publications

References 42 publications

Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery

Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery

Cytotoxicity of multifunctional surfactant containing capped mesoporous silica nanoparticles

Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release

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