Synthesis of pH-sensitive crosslinked guar gum-g-poly(acrylic acid-co-acrylonitrile) for the delivery of thymoquinone against inflammation

Pal, Ravi Raj; Kumar, Deepak; Raj, Vinit; Rajpal, Vasundhara; Maurya, Priyanka; Singh, Samipta; Mishra, Nidhi; Singh, Neelu; Singh, Priya; Tiwari, Nidhi; Saraf, Shubhini A.

doi:10.1016/j.ijbiomac.2021.05.072

Cited by 29 publications

(1 citation statement)

References 56 publications

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“…Hydrophobically modified guar gum loaded with antibiotics (gentamicin, amoxicillin) also presented bactericidal ( Staphylococcus aureus , Escherichia coli ) and antifungal ( Candida albicans ) activity, favoring its use as wound dressing [ 164 ]. Crosslinked guar gum-g-poly (acrylic acid-co-acrylonitrile) is efficient in a medium with different pH to deliver thymoquinone and inhibit inflammation [ 165 ]. Another pH-responsive guar gum-based gel, a blend with sodium alginate and polyvinyl alcohol, showed a good release profile of verapamil hydrochloride [ 166 ], confirming the robustness of guar gum-based gels for drug delivery.…”

Section: Plant-derived Polymersmentioning

confidence: 99%

Plant Polysaccharides in Engineered Pharmaceutical Gels

et al. 2022

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Hydrogels are a great ally in the pharmaceutical and biomedical areas. They have a three-dimensional polymeric structure that allows the swelling of aqueous fluids, acting as an absorbent, or encapsulating bioactive agents for controlled drug release. Interestingly, plants are a source of biogels, specifically polysaccharides, composed of sugar monomers. The crosslinking of these polymeric chains forms an architecture similar to the extracellular matrix, enhancing the biocompatibility of such materials. Moreover, the rich hydroxyl monomers promote a hydrophilic behavior for these plant-derived polysaccharide gels, enabling their biodegradability and antimicrobial effects. From an economic point of view, such biogels help the circular economy, as a green material can be obtained with a low cost of production. As regards the bio aspect, it is astonishingly attractive since the raw materials (polysaccharides from plants-cellulose, hemicelluloses, lignin, inulin, pectin, starch, guar, and cashew gums, etc.) might be produced sustainably. Such properties make viable the applications of these biogels in contact with the human body, especially incorporating drugs for controlled release. In this context, this review describes some sources of plant-derived polysaccharide gels, their biological function, main methods for extraction, remarkable applications, and properties in the health field.

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Section: Plant-derived Polymersmentioning

confidence: 99%

Plant Polysaccharides in Engineered Pharmaceutical Gels

et al. 2022

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Synthesis of pH‐sensitive grafted psyllium: Encapsulation of quercetin for colon cancer treatment

Kumar

Gautam

Kundu

2021

J of Applied Polymer Sci

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The pH-sensitive polymeric materials are the current need of time in targeted drug delivery applications. The pH-sensitive cross-linked psyllium grafted-poly (acrylonitrile-co-acrylic acid) [Psy-g-Poly (An-co-AA)] was synthesized by using ceric ammonium nitrate (CAN) redox initiator via chemical grafting process for colon cancer treatment. The synthesized material [Psy-g-Poly (An-co-AA)] was characterized by nuclear magnetic resonance, Fourier transform infrared, scanning electron microscopy, X-ray diffraction Zeta potential, and thermal gravimetric analysis. Furthermore, quercetin (QPN) drug was encapsulated in cross-linked grafted psyllium preparing nanoparticles of encapsulated QPN via the sonication technique for controlled release of QPN and testing of in vitro anticancer and antioxidant activities. The anticancer activity of QNP and QPN were studied on human cell line (HCT-15) and it was observed that QNP also exhibited excellent anticancer and antioxidant activity as compared to only QPN. QNP showed maximal swelling at pH-7 and demonstrated maximum QPN release (93%) at the pH of the intestinal fluid (pH-7.4). The drug release kinetic data followed the Korsmeyer-Peppas model (R 2 = 0.9808) kinetic model, indicating the mechanism of drug release from QNP was non-Fickian diffusion. Furthermore, pH-specific QPN release behavior of Psy-g-Poly (An-co-AA) can be utilized for colon targeted drug delivery.

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