Synthesis of Phthalyl Substituted Imidazolones and Schiff Bases as Antimicrobial Agents

Sah, Pramilla; Saraswat, Neha; Manu, Manu

doi:10.1155/2011/726315

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…On the other hand, esters of 1,1-cyclopropane dicarboxylic acid were found to possess important insecticidal activity (Ronald and Leland 1998). Furthermore bulk of literature is available to explore the biological importance of Schiff bases (Ibrahim et al, 2011;Sah et al, 2011;Sanjeeva et al, 2010) especially antimicrobial and thus aroused our interest in the synthesis of some novel bis Schiff bases. Based on the wide spectrum of biological profile of 1,1-propane dicarboxylic acid, thiadiazole, Schiff base and their importance in pharmaceutical, biological field and in continuation of our ongoing research on biologically active heterocycles (Panwar et al, 2006;Goel et al, 2004;Kumar et al, 2003;, it was thought of interest to accommodate 1,1-propane dicarboxylic acid, thiadiazole and aryl aldehydes in a single molecular frame work of designing to synthesize some novel bis heterocycles for enhancing biological activity with lesser toxicity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Pharmacological Evaluation: Antimicrobial, Anti-Inflammatory, Analgesic, Ulcerogenic Properties of Several Bis-Heterocyclic Derivatives

Kumar¹,

Panwar²

2015

Indonesian J. Pharm.

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In Medicinal chemistry, heterocyclic derivatives contributed the largest classical division of organic chemistry. Thiadiazole compounds have been known for many biological activities such as hypoglycemic, anticancer, anti-inflammatory, anti-asthmatic, antihypertensive etc. On this research, several 1,1-bis [2-{2-(5-(arylidene)imino-1,3,4-thiadiazol-2-yl) methyl amino}-1,3,4-thiadiazo-5-yl] cyclopropane 5(a-h) have been synthesized from cyclopropane dicarboxylic acid comprising thiadiazole moieties. All the synthesized compounds have been characterized by elemental (C,H,N) and spectral (I.R., 1 H-NMR, Mass) analysis. Furthermore, all synthesized compounds were screened for their antifungal, antimicrobial, anti-inflammatory, analgesic, ulcerogenic and toxic activities. The Compound 5f, 3-chlorophenyl substituted was found the most potent in antimicrobial spectrum against all the used microbes. On the other hand, compound 5g, 4-hydroxy-3-methoxy phenyl substituted was found the most potent in antiinflammatory, analgesic, and ulcerogenic activities which further evaluated for lesser toxicity test.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Pharmacological Evaluation: Antimicrobial, Anti-Inflammatory, Analgesic, Ulcerogenic Properties of Several Bis-Heterocyclic Derivatives

Kumar¹,

Panwar²

2015

Indonesian J. Pharm.

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“…Schiff bases derived from aromatic amines and aromatic aldehydes have a wide variety of applications in many �elds, for example, biological, inorganic, and analytical chemistry [1][2][3][4]. In addition, Schiff bases and heterocyclic ring are important class of compounds in medicinal and pharmaceutical �eld [5][6][7][8]. Recently, in our previous work, Schiff bases show biological properties including antibacterial, antifungal antitumor, analgesic, and anti-in�ammatory activities [9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff′s Base Derivatives

Sabry

Flefel²,

Al-Omar

et al. 2012

Journal of Chemistry

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A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine(2a,b)and corresponding Schiff's bases(3a–j)were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines(1a,b)as starting materials. The compounds1a,bwere reacted with 2,3,4,5-tetrachlorophthalic anhydride in glacial acetic acid to give the corresponding bis-imides(2a,b). But they are treated with aromatic aldehydes in refluxing ethanol to afford the Schiff’s base derivatives(3a–j). The antimicrobial screening showed that many of these newly synthesized compounds had good antimicrobial activities comparable to streptomycin and fusidic acid as positive controls. The detailed synthesis, spectroscopic data, and antimicrobial activities of the synthesized compounds were reported.

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“…While optimizing the reaction conditions of the Biginelli reaction, we found that treatment of β-keto ester , aryl aldehyde and urea with KSF montmorillonite in methanol afforded DHPMs in good to excellent yields [8].A simple, efficient and cost-effective method has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H) -ones by a one-pot three component cyclocondensation reaction of 1,3-dicarbonyl compound, aldehyde, and urea ,thiourea using benzyltriethylammonium chloride as the catalyst, under solvent-free conditions: the scope of this protocol is utilized for the synthesis of mitotic kinesin EG5 inhibitor monastrol. [9] Experimental:-Melting points were recorded with Gallenkamp melting points Apparatus and were uncorrected . Elemental analysis was carried out in perkin-Elmer 2400 CHN Elemental analyzer table…”

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confidence: 99%

Synthesis, Characterization and Kinetic Studies of Some Oxazepine and Oxazepane Derivatives

F. AL-Hity,

F.Al-Rawi,

A.Al-Hadithi

2012

JUAPS

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Bis(2-hydroxy-benzylidene)-Thiourea and 1,3-Bis-(dimethylaminobenzylidene)-Thiourea were prepared by condensation of Thiourea with one equivalent and two equivalent of substituted benzaldehyde. These Schiff-bases were reacted with one equivalent of Maleic , Succinic and Phthalic anhydride in absolute ethanol to give 7-membered heterocyclic ring system of 2-(2-Hydroxy-phenyl)-4,7dioxo-4,7-dihydro-[1,3] oxazpine-3-carbothioic acid amide and 2-(4-Dimethylaminophenyl)-4,7-dioxo-4,7-dihydro-[1,3]oxazepine-3-carbothioiacid amide, 1,3-Bis(2hydroxy-benzylidene)-Thiourea and 1,3-Bis-(dimethylamino-benzylidene)-Thiourea were reacted with two equivalent of Maleic and Succinic anhydride in same solvent to give 2 (7-membered) heterocyclic ring system of 2-(2-hydroxy-phenyl)-3-[2-(2hydroxy-phenyl)-4,7-dioxo-[1,3]oxazepine-3-carbothioyl]-2,3-dihydro-[1,3]oxazepine-a,7-dione and 2-(4-Dimethylamino-phenyl)-3-[2-(4-dimethylaminophenyl)-4,7-dioxo-[1,3]oxazepine-3-carbothioyl]-2,3-dihydro-[1,3]oxazepine-4,7dione. The constants of reaction velocity for (Schiff-bases)with Maleic , Succinic andPhthalic anhydride were studied and showed that the reaction wsa firstorder one .Some of thermodynamic characteristics were evaluated and showed differences among the prepared compounds . The final products were identified by their melting points, elemental analysis, IR, 1H NMR and UV-Visible spectra.

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Synthesis of Phthalyl Substituted Imidazolones and Schiff Bases as Antimicrobial Agents

Cited by 4 publications

References 3 publications

Synthesis and Pharmacological Evaluation: Antimicrobial, Anti-Inflammatory, Analgesic, Ulcerogenic Properties of Several Bis-Heterocyclic Derivatives

Synthesis and Pharmacological Evaluation: Antimicrobial, Anti-Inflammatory, Analgesic, Ulcerogenic Properties of Several Bis-Heterocyclic Derivatives

Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff′s Base Derivatives

Synthesis, Characterization and Kinetic Studies of Some Oxazepine and Oxazepane Derivatives

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