Synthesis of Some Glycidic Hydrazides and Amides as Potential Psychotropic Agents and Anticholinergic Agents

Saenz, R. V.; Brown, Robert G.; Isaacson, Eugene I.; Delgado, Jaime N.

doi:10.1002/jps.2600590704

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Hydrazides have various applications as drugs, chemical preservers for plants, in industry, glues and for many other purposes . Hydrazides are also possessed other biological activities like antituberculous , antifungal and psychotropic , antiviral , antiparasite , and anti‐phytopathogenic activity . In addition, they were found to be useful in treatment of respiratory diseases, cardiovascular diseases, tumors, hemorrhage, sepsis, and fever .…”

Section: Introductionmentioning

confidence: 99%

New 1,3,4‐Thiadiazole Derivatives: Synthesis, Characterization, and Antimicrobial Activity

Abo‐Bakr

Hashem

2019

Journal of Heterocyclic Chem

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In the present study, 2,5‐bis(mercapto‐acetichydrazide)‐1,3,4‐thiadiazole (1) was utilized by different reagents, namely, ethoxymethylene malononitrile, ethoxymethylene ethyl cyanoacetate, triethyl orthoformate, phenyl isothiocyanate, carbon disulfide, isatin, acetophenone, cyclohexanone, different aldehydes, and different anhydrides, to yield a new series of 2,5‐disubstituted‐1,3,4‐thiadiazoles 2–18. The chemical structure of these products was characterized by the spectral data IR, 1H‐NMR, 13C‐NMR, MS, and elemental analysis. All the synthesized compounds were screened for their antibacterial activity.

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