Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity

Antimicrobial Activities of Some Synthetic Flavonoids

“…Moreover, compounds (3) and (4) exhibited weak activity against the Gram-negative fungi each with 9 and 7 mm inhibition zone against K. pneumoniae and 7 and 8 mm against P. aeroginosa both with MIC of 500 µg/ml. Compounds (1), (2), (7), (8) and (9) were inactive against all the tested microorganisms and their MIC results showed high turbidity at various concentrations justifying their inactivity. Compounds (3), (4), (5) and (6) showed very weak activity against A. fumigatus and C. glabrata with a very low zone of inhibition and high MIC compared to the standard control (Nystasin) as shown in Table II.…”

“…Scientific studies involving pharmaceutical drug potencies of flavonoids are extensively examined in the past several years and are increasing [8]. Chalcones been the precursors of various biologically important heterocyclic compounds have a reactive α,β-unsaturated carbonyl group which was found to be responsible for their antimicrobial activities.…”

Recent developments in biological activities of chalcones: A mini review

“…Furthermore, the SAR study indicated that the asymmetric compounds possessed higher anti-inflammatory activity than their symmetric analogues, while the electro-negativity and molecular polarizability were considered as important factors for the inhibition of LPS-induced IL-6 expression. Bano and co-workers reported [112] the synthesis and antiinflammatory evaluation of novel chalcones (118) on carrageenan-induced hind paw oedema model using the dose of 20 mg/kg body weight (Fig. 32).…”

Synthesis and Cytotoxic Activity of New Chalcones and their Flavonol Derivatives

“…Chalcone-triazolecoumarin hybrids were reported by Pingaew et al as anticancer and antimalarial agents [10]. It has been reported that chalcones possess many important biological activities including anti-oxidant [11], anticancer [12], anti-bacterial [13], anti-fungal [14], antiparasitic [15], antivascular [16] and anti-inflammatory [17]. Recently Tatiana et al reported the anticancer activities of chalcone and flavonol derivatives [18].…”