Synthesis of some novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones as biologically potent agents

Abstract

A series of novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones 6a‐h have been synthesized by cyclocondensation of thioglycolic acid with methylene‐bis‐(N‐cyclohexylidene‐N‐pyrimidine) 5a‐h, which in turn have been prepared by the reaction of cyclohexanone with methylene‐bis‐2‐aminopyrimidines 4a‐h, which are prepared by the reaction of guanidine hydrochloride with methylene‐bis‐chalcones 3a‐h. The compounds 3a‐h have been synthesized by the reaction of 5‐(3‐formyl‐4‐hydroxybenzyl)‐2‐hydroxybenzaldehyde 2 with various acetophenones in presence of KOH. The compound 2 is prepared by the reported method. The structures of the compounds synthesized have been confirmed by their elemental analysis and spectral data. Their antibacterial and antifungal activities have also been evaluated.

Synthesis and Biological Evaluation of Triazole linked Thiazolidenone Glycosides

“…Following the successful introduction of antimicrobial and nematicidal agents, inspired by the biological profile of triazoles, thiazolidenones, and in the continuation of our work on biologically active heterocycles, [27][28][29][30][31][32][33][34][35][36][37][38][39] we have developed a series of novel triazole linked thiazolidenone derivatives, and evaluated their nematicidal activity along with antibacterial activity.…”

Microwave-Assisted Synthesis and Anticancer Activity of Triazolyl Thiazolidine Derivatives of Pyrene

“…Following the successful introduction, inspired by the biological profile of triazoles, thiazolidinones, and in the continuation of our work on biologically active heterocycles [37][38][39][40][41][42][43][44][45][46] we have developed a series of novel triazolyl thiazolidine derivatives of pyrene, and evaluated their anticancer activity.…”

Microwave-assisted Synthesis of Hybrid Heterocycles as Potential Anticancer Agents

“…Following the successful introduction of triazoles and thiazolidinones, microwave-assisted MCR reactions, inspired by the biological profile of triazoles, thiazolidinones, and in the continuation of our work on biologically active heterocycles [18][19][20][21][22][23][24][25][26][27][28][29] we have developed a series of novel triazole-linked thiazolidenone derivatives, we have investigated the application of microwave irradiation for the synthesis of our hybrid molecules and evaluated their anticancer activity.…”