Synthesis of steroidal dihydropyrazole derivatives using green ZnO NPs and evaluation of their anticancer and antioxidant activity

Insight into the Potential Antioxidant and Antidiabetic Activities of Scrolled Kaolinite Single Sheet (KNs) and Its Composite with ZnO Nanoparticles: Synergetic Studies

“…Besides their low production cost and unique physicochemical properties, metal oxide nanoparticles are characterized by significant biological activity, therapeutic and theranostic potentiality, and biocompatibility [14][15][16][17][18]. Zinc oxide is one of the most investigated metal oxides as bioactive material that is characterized by its biocompatibility, nontoxicity, antidiabetic, and antioxidant properties [18][19][20][21][22]. The zinc element in the human body is one of the most biologically active and vital elements, and it is very effective during the formation reactions of nucleic acid and protein [15,20].…”

“…Zinc oxide is one of the most investigated metal oxides as bioactive material that is characterized by its biocompatibility, nontoxicity, antidiabetic, and antioxidant properties [18][19][20][21][22]. The zinc element in the human body is one of the most biologically active and vital elements, and it is very effective during the formation reactions of nucleic acid and protein [15,20]. Therefore, zinc and zinc oxide are widely used in several biological, medical, and pharmaceutical applications including their use as drug carriers, antibacterial agents, anticancer agents, hypoglycemic agents, and antioxidant agents in addition to their vital role in the tissue engineering industry [15,23].…”

“…Surface modifications and hybridization of the synthetic ZnO particles by the different physical and chemical methods were suggested as enhancement techniques for their biocompatibility, biological activity, and genotoxicity in addition to their antibacterial and antioxidant properties [15,18,26]. The commonly used modification techniques are: (1) elemental doping of ZnO crystal structure, (2) integrating the ZnO particles in composites with other metal oxides, (3) supporting the synthetic ZnO particles into effective carriers or substrates, (4) integrating the synthetic ZnO particles in composites with biologically active biopolymers, and (5) synthesis of the ZnO grains in chemical complexes with the known active phytochemicals from the extracts of the plants [14,20,27,28].…”

Biological Activities of Sargassum Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents

“…Among these metal oxides, synthetic ZnO nanoparticles and their composites have been extensively applied as promising bioactive materials that exhibit significant biocompatibility, nontoxicity, and antioxidant and anti-diabetic properties [17][18][19]. Zinc is a vital bioactive element in the human body, especially during the production of nucleic acids and proteins [15,19].…”

“…Among these metal oxides, synthetic ZnO nanoparticles and their composites have been extensively applied as promising bioactive materials that exhibit significant biocompatibility, nontoxicity, and antioxidant and anti-diabetic properties [17][18][19]. Zinc is a vital bioactive element in the human body, especially during the production of nucleic acids and proteins [15,19]. Additionally, synthetic zinc oxides and their base materials are extensively used in pharmaceutical, medical, and biological industries as antioxidant, anticancer, hypoglycemic, and antibacterial agents, in addition to their vital role as drug delivery systems and use in tissue engineering industries [15,20].…”