Synthesis of Talosin A and B, Two Bioactive Isoflavonoid Glycosides

Wu, Zhongtao; Lian, Gaoyan; Yu, Bo; Wang, Zhenzhong; Zhao, Yuanyuan; Xiao, Wei

doi:10.1002/cjoc.201090291

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Glycosylation With Glycosyl Fluorides1

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2010

2024

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Cited by 6 publications

(1 citation statement)

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“…56 We achieved a concise synthesis of this molecule using a glycosyl fluoride as donor via tactic I (Scheme 15). 57 To improve the solubility of genistein, its three hydroxyl groups were persilylated to yield isoflavone 76. Promoted by boron trifluoride, talopyranosyl fluoride 77 was condensed with isoflavone 76 to provide 4′,7-O-bisglycoside 78 (45%).…”

Section: Glycosylation With Glycosyl Fluoridesmentioning

confidence: 99%

Glycosylation Reactions in the Synthesis of Flavonoid Glycosides

Sun

Laval

2014

Synthesis

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Section: Glycosylation With Glycosyl Fluoridesmentioning

confidence: 99%

Glycosylation Reactions in the Synthesis of Flavonoid Glycosides

Sun

Laval

2014

Synthesis

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The Secondary Metabolites from Genus Kitasatospora: A Promising Source for Drug Discovery

Wei,

Wang,

et al. 2024

Chemistry & Biodiversity

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Microbial secondary metabolites are well‐known resource for drug discovery. Kitasatospora is one of the rare genera of Actinomycetes and important antibiotics producer that are not fully explored. Recently an explosively increasing number of reports have proved that the genus is capable of producing various bioactive secondary metabolites. Here, we comprehensively summarized secondary metabolites from Kitasatospora strains including their chemical structures, biological effects, mechanisms of actions together with the related genomic and biosynthetic analyses. The review covered more than 100 metabolites with their significant pharmacological properties which included a class of peptide aldehyde natural products that had been optimized to a promising lead compound. This work provides detailed information of Kitasatospora‐derived natural products and presents their potential for therapeutically relevant utilization, which would inspire the drug discovery from this genus in future.

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