Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry

Shang, Pei; Wu, Jie; Shi, Xiaoyu; Wang, Zhidan; Song, Fei; Liu, Shouxin

doi:10.3390/polym11050765

Cited by 6 publications

(6 citation statements)

References 45 publications

(51 reference statements)

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“…The gel has a tendency to shrink and lose water at 40 °C, which proves that the gel has temperature sensitivity. This is because, when the temperature rises to 40 °C, the hydrogen bond breaks, and the temperature-sensitive polymer chain P(MEO 2 MA- co -OEGMA) chain begins to shrink [ 39 ] by squeezing water out of the gel. Thus, this shows a state of de-swelling.…”

Section: Resultsmentioning

confidence: 99%

Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels

Wang

Shi

et al. 2020

Polymers

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Physical crosslinking and chemical crosslinking were used to further improve the mechanical properties and stability of the gel. A temperature/pH dual sensitive and double-crosslinked gel was prepared by the stereo-complex of HEMA-PLLA20 and HEMA-PDLA20 as a physical crosslinking agent, ethylene glycol dimethacrylate (EGDMA) as a chemical crosslinking agent, and azodiisobutyronitrile (AIBN) as an initiator for free radical polymerization. This paper focused on the performance comparison of chemical crosslinked gel, a physical crosslinked gel, and a dual crosslinked gel. The water absorption, temperature, and pH sensitivity of the three hydrogels were studied by a scanning electron microscope (SEM) and swelling performance research. We used a thermal analysis system (TGA) and dynamic viscoelastic spectrometer to study thermal properties and mechanical properties of these gels. Lastly, the in vitro drug release behavior of double-crosslinked hydrogel loaded with doxorubicin under different conditions was studied. The results show that the double-crosslinked and temperature/pH dual responsive hydrogels has great mechanical properties and good stability.

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Section: Resultsmentioning

confidence: 99%

Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels

Wang

Shi

et al. 2020

Polymers

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“…Results showed that due to the hydrogen bonds formed between water molecules and the oligo (ethylene glycol) graft chain that is hydrophilic, the synthesized copolymer showed better solubility in water and formed a clear solution, compared to just PEG-PCL-PEG, which displayed a cloudy solution in water. In addition, the improvement in the thermo-responsiveness of the copolymer was attributed to the OEGMA and MEO2MA molecules, and the formulation showed a gelation temperature of 30 • C (Shang et al, 2019).…”

Section: Pcl-peg Based Thermogelsmentioning

confidence: 99%

“…The solubility and temperature responsiveness of PEG-PCL based thermogels was improved via the synthesis of a mPEG-b-[PCL-g-(MEO2MA-co-OEGMA)]-b-mPEG blockgraft copolymer by Shang et al (2019). Results showed that due to the hydrogen bonds formed between water molecules and the oligo (ethylene glycol) graft chain that is hydrophilic, the synthesized copolymer showed better solubility in water and formed a clear solution, compared to just PEG-PCL-PEG, which displayed a cloudy solution in water.…”

Section: Pcl-peg Based Thermogelsmentioning

confidence: 99%

Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications

et al. 2020

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Targeted and controlled drug delivery employing "smart materials" is a widely investigated field, within which stimuli-responsive polymers, particularly those which are thermo-responsive, have received considerable attention. Thermo-responsive polymers have facilitated the formulation of in situ gel forming systems which undergo a sol-gel transition at physiological body temperature, and have revolutionized the fields of tissue engineering, cell encapsulation, and controlled, sustained delivery of both drugs and genes. However, the use of single thermo-responsive polymers in the creation of these systems has posed numerous problems in terms of physico-mechanical properties, such as poor mechanical strength, high critical gelation concentrations (CGC) resulting in increased production costs and solutions that are too viscous, toxicity, as well as gelation temperatures that are incompatible with physiological body temperatures. Hybridization of these thermo-responsive polymers with other polymers has therefore been employed, resulting in the creation of tailor-made drug delivery systems that have optimal gelation temperatures and concentrations, ideal viscosities and improved gel strengths. This article reviews various thermo-responsive polymers that have been employed in the formulation of thermo-gelling systems. Special attention has been given to the hybridization of each of these polymers, the resulting systems that have been created, and their biomedical applications.

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“…A 3D and interconnected structure, similar to that of the extracellular matrix, was obtained through the hybridization of PEG-PCL with PNIPAAm, resulting in a penta-block PNIPAAm-PCL-PEG-PCL-PNIPAAm TSH for application in wound healing. [70] Such formulation displayed excellent biocompatibility and was able to gel at 37 °C, its pore size being ideal for fibroblast attachment as well as for the improvement of cell adhesion and proliferation. [70] The focus of this review is driven by PNIPAAm hydrogel and its derivatives.…”

Section: Pcl-peg-based Thermosensitive Hydrogelsmentioning

confidence: 99%

“…[70] Such formulation displayed excellent biocompatibility and was able to gel at 37 °C, its pore size being ideal for fibroblast attachment as well as for the improvement of cell adhesion and proliferation. [70] The focus of this review is driven by PNIPAAm hydrogel and its derivatives. Therefore, a detailed description of its chemical structure and relationship with the LCST transition, synthesis, and main properties are provided in the following sections.…”

Section: Pcl-peg-based Thermosensitive Hydrogelsmentioning

confidence: 99%

Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

et al. 2023

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Temperature‐sensitive (thermosensitive) hydrogels, which are part of the family of stimulus‐sensitive hydrogels, consist of water‐filled polymer networks that display a temperature‐dependent degree of swelling. Thermosensitive hydrogels, which can undergo phase transition or swell/de‐swell as temperature changes, have great potential in various technological and biomedical purposes for a number of reasons: their temperature response is reversible, hydrogels are stable and easy to prepare, they can be biocompatible and also be suitably combined with other organic and inorganic materials, resulting in new materials with outstanding properties. Among thermosensitive hydrogels poly(N‐isopropylacrylamide) (PNIPAAm) is the most extensively studied because it brings together the best properties of these materials. Consequently, in the past few years, a wide number of applications and new chemical processes to prepare PNIPAAm and their derivatives are being proposed. The objective of this review is to summarize the fundamentals of thermosensitive hydrogels and recent advances in preparation and both technological and biomedical applications of thermosensitive hydrogel, with a special focus on PNIPAAm and their derivatives. Special attention has been given to the discussion of challenges and future research perspectives based on new horizons not yet considered.

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Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry

Cited by 6 publications

References 45 publications

Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels

Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels

Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications

Recent Advances in Poly(N‐isopropylacrylamide) Hydrogels and Derivatives as Promising Materials for Biomedical and Engineering Emerging Applications

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