Synthesis, photophysical and photobiological characterization of BSA nanoparticles loaded with chloroaluminium phthalocyanine by one-step desolvation technique for photodynamic therapy action

Abreu, Alexandro da Silva; Carvalho, Janicy Arantes; Trindade, Agnes Cecheto; Beltrame, Milton; Simioni, Andreza Ribeiro

doi:10.1080/09205063.2019.1650241

Cited by 10 publications

(1 citation statement)

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“…[5][6][7] The structures and properties of AIEgens are quite different from the traditional aggregation caused quenching (ACQ) or their aggregates exhibit some limitations in multifunctional biological research on account of their large size, low targeting efficiency, poor biocompatibility, and stability in physiological fluids. [15,16] To overcome these defects, some assembled AIEgen-based multifunctional materials have been constructed, [17] such as AIEgen-silica, [18,19] AIEgen-BSA, [20,21] AIEgen-chitoson, [22] and AIEgen-lipid. [23] Among various types of clinically used formulations, lipidbased carriers hold a big share for their incomparable advantages, such as excellent biocompatibility, [24,25] negligible optical interference, [26] diverse modifiable groups, [27] high water-solubility, and stability.…”

Section: Introductionmentioning

confidence: 99%

AIEgen–lipid structures: Assembly and biological applications

Cao

Yang

2020

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Aggregation‐induced emission (AIE) molecules possess notable advantages outperforming traditional aggregation caused quenching (ACQ) materials on various aspects. They are rapidly developed these years. More and more AIE luminogens (AIEgens) are designed to possess multifunctions such as the abilities of near‐infrared two‐photon absorption and reactive oxygen species (ROS) generation, which could be used for deep tissue imaging and photodynamic therapy. The AIEgens exhibit great potential in biological application field. However, despite the photophysics stability and ROS generation ability in aggregated states are favorable conditions, their applications in biological field are retarded by uncontrolled size, single imaging mode, low targeting efficiency, and also poor biocompatibility and dispersibility in physiological environment. The combination of AIEgen and lipid is a straightforward, promising, and intensively used way to solve the above problems. Due to the special amphipathic property of lipid, which results from a hydrophilic head and hydrophobic tail structure, there are various possibilities of combination modes between lipid and AIEgen. Even a little procedure or condition change during the synthesis process will impact the structure of obtained product, which can further influence its application. Herein, we summarize the synthesis methods of different AIEgen–lipid compounds with diverse structures and properties, as well as their biological applications in this contribution, which has not been presented before, being aimed at serving as a synthesis and application reference for these promising AIEgen–lipid compounds applied in biological region.

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