Synthesis, Spectroscopic Characterization and Biological Evaluation of Ni(II), Cu(II) and Zn(II) Complexes of Diphenyldithiocarbamate

Abstract

Khan, et al.: Diphenyldithiocarbamate Complexes Synthesis and Biomedical Application Ni(II), Cu(II) and Zn(II) complexes of diphenyldithiocarbamate have been synthesized with the aim of developing antioxidants, potential antibacterial and antifungal agents. Synthesized metal complexes were characterized by magnetic susceptibility, elemental analysis; conductivity measurements, mass spectra, infrared, ultra violet/visible and nuclear magnetic resonance verified the chemical composition of products. Magnetic susceptibility and spectroscopic studies suggested the predicted geometry of the diphenyldithiocarbamate complexes as octahedral geometry of Ni(II) complex distortion square-planer geometry distorted towards tetrahedral for Cu(II) and Zn(II) complexes. Synthesized metal complexes exhibited remarkable antioxidant potential as compared to standard. Zn(II) complex of diphenyldithiocarbamate exhibited IC 50 of 31.45± 0.31 μM while the standard, butylated hydroxytoluene exhibited IC 50 of 44.67±0.45 μM antioxidant activity. Synthesized metal complexes showed very good antibacterial and antifungal potential against Rhodococcuss, Actinomyces viscosus, Bacillus subtilis, Escherichia coli and the fungi, Aspergillus niger, Aspergillus flavus, Candida and Acetomyceta. It's concluded that synthesized metal complexes showed better antioxidant, antibacterial and antifungal potential as compared to diphenyldithiocarbamate as well as the standard and might turn out to be a valuable treatment of numerous kinds of diseases.

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

“…An aqueous-methanol seed extract was concentrated by the removal of excess quantity of solvent (water and methanol) using a rotary evaporator. The crude extract was refrigerated in an airtight bottle in a refrigerator for future use [15].…”

“…A standard protocol was followed to determine the total protein content of the tissues 14]. Enzymatic antioxidants were assayed by determining glutathione peroxidase (GPx) [15], catalase (CAT) [17], and superoxide dismutase (SOD) [18], while the estimation of nonenzymatic anti-oxidants was done through reduced glutathione (GSH) [14] and lipid peroxidation (LPO) [15].…”

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

“…The electronic spectrum of the free ligand ( Figure S4 ) exhibited two absorption bands, at 263 nm and 286 nm, attributed to the π-π * transition of the N–C=S and S–C=S [ 37 ] In the complexes, the Cu(II) complex exhibited two bands, the intense band at 276 nm attributed to intra-ligand charge transfer transitions mainly associated with N–C=S and S–C=S moieties, and a broad absorption band at 441 nm assigned to the d-d transition for copper(II) in a square planar geometry [ 38 ]. The electronic spectrum of the Zn(II) complex showed one broad band at 346 nm that resulted from its d 10 configuration, attributed to the intra-ligand charge transfer transition [ 39 ].…”

Insights into the Antimicrobial Potential of Dithiocarbamate Anions and Metal-Based Species

“…and four fungal strains (A. niger, A. flavus, C. albicans, and Acetomyceta sp.) [40]. Among the evaluated complexes, the zinc(II) species was the most potent against all the bacterial species tested while the copper(II) derivative showed the highest antifungal activity; both zinc(II) and copper(II) derivatives also presented greater activity than the standards (ampicillin and fluconazole) employed in the study.…”

“…Khan et al evaluated the activities of the diphenyl dithiocarbamates, M(L 7 ) 2 for M(II) = Ni, Cu and Zn [40]. Noteworthy from this study was that each of the metals exhibits a distinctive efficacy against four bacterial strains (B. subtilus, P. aeruginosa, E. coli, and Rhodococcus sp.)…”