Synthesis, structural characterisation and antibacterial activities of lead(II) and some transition metal complexes derived from quinoline-2-carboxaldehyde 4-methyl-3-thiosemicarbazone

Damit, Nurin Sakinatul Hayati Haji; Hamid, Malai Haniti S. A.; Rahman, Nur Sabrina Rahayu Haji Abdul; Ilias, Siti Nor Hashimah Haji; Keasberry, Natasha Ann

doi:10.1016/j.ica.2021.120557

Cited by 25 publications

(3 citation statements)

References 40 publications

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“…2-butyl thioquinazoline-4-(3 H )-thiosemicarbazone ( 86 ) was added to Co(II), Ni(II), and Cu(II) salts in refluxing ethanol reflux for 3–4 h, and the reaction afforded 2-butyl thioquinazoline-4-(3 H )-thiosemicarbazone complexes 87a – h in 60–65% yields [ 97 ] ( Scheme 43 ). These complexes were also subjected to study their antimicrobial screening against, Gram-positive bacteria Candida albicans and Gram-negative bacteria Escherichia coli by disc diffusion technique [ 97 ].…”

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

et al. 2023

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: This review focuses on some interesting and recent applications of transition metals towards the complexation of thiosemicarbazides, thiocarbohydrazides, and their corresponding carbazones. We started the review with a description of the chosen five metals, including Cu[Cu(I), Cu(II], Co(II), Ni(II), Pd(II), and Ag(I) and their electronic configurations. The stability of the assigned complexes was also discussed. We shed light on different routes describing the synthesis of these ligands. We also reported on different examples of the synthesis of Cu(I), Cu(II), Co(II), Ni(II), Ag(I), and Pd(II) of thiosemicarbazide and thiocarbohydrazide complexes (until 2022). This review also deals with a summary of the fruitful use of metal complexes of thiosemicarbazones and thiocarbazones ligands in the field of catalysis. Finally, this recent review focuses on the applications of these complexes related to their biological importance.

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Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

et al. 2023

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“…[1][2][3] The most striking biological properties include anti tumorous, antioxidant, antibacterial, antifungal, anticancerogenic,besides showing insulinmimeticeffects. [4][5][6][7][8][9][10][11][12] thiosemicarbazones exist in thione and thienol forms both in solution and solid state, most strikingly thione form stays in solution phase.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral, Antimicrobial and In vitro Antitumorous Studies of Copper based mulltidentate thiosemicarbazones

Mathew¹,

Jacob²

2023

Orient. J. Chem

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This is a report of the studies conducted on the synthesis, spectral, biological viz. antibacterial and antitumorous activities of some Copper complexes synthesized from a multidentate thiosemicarbazone ligand, HL2. This is based on a reaction between a secondary amine viz.N-phenyl piperazine and an N-substituted heterocyclic ketone viz. 2-Benzoylpyridine. The ligand exhibits a multidentate mode of coordination through N,N,S donor atoms in the copper complexes. The electron paramagnetic Resonance studies of the complexes(solution spectra) at LNT in DMF shows typical axial spectra with distinct g-values, gǁ& g┴indicating a slightly distorted four coordinated planar geometry. The biological studies viz. antibacterial and antitumorous studies suggest their use as competent antibacterial and antitumor agents.

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“…The most common one is as N,S bidentate chelate [3,4], coordination mode that affords the formation of a very stable five-membered chelate ring, but many others are described in the literature, for example S monodentante [5,6], N,S bidentate chelate and S bridge [7,8] Crystals 2022, 12, 310 2 of 12 or N,S bidentate chelate and N bridge [9]. This, together with the control of protonation/deprotonation and the nature of auxiliary anions, lead to the formation of different structures such as monomers [10][11][12], dimers [13][14][15] or coordination polymers [16][17][18]. In addition to their fascinating structural properties, TSCs have a wide range of applications in different fields as catalysis [19][20][21], metal detoxification [22][23][24], metal sensing [25][26][27] or medicine [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Reaction Conditions in the Crystal Structures of Zn(II) and Ni(II) Coordination Compounds with a Dissymmetric Bis(Thiosemicarbazone) Ligand

et al. 2022

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The new ligand HMeATSM, derived from condensation of 2-3-butanedione with 4-methyl-3-thiosemicarbazide and 2,4-dimethyl-3-thiosemicarbazide, has been synthesized. Its reactivity with nickel(II) and zinc(II) nitrates was explored and the resulting complexes were thoroughly characterized by elemental analysis, conductivity, mass spectrometry, IR, 1H and 13C NMR spectroscopies and their structures were confirmed by single-crystal X-ray diffraction. The results showed that the complex [Ni(MeATSM)]NO3 1 is formed under every reaction condition. In contrast, the reaction with zinc(II) nitrate depends on the temperature and the presence of LiOH.H2O, leading to the obtaining of complexes [Zn(MeATSM)(OH2)](NO3) 2 and [Zn(Me2TS)2(OH2)](NO3)2 3. The crystal structures of complexes 1 and 2 show that the dissymmetric ligand acts as a N2S2 tetradentate monoanionic ligand. The structural preferences of the metals also determine the structure of the complexes: whereas nickel(II) is in a square-planar environment, the zinc atom prefers a distorted square-base pyramid geometry imposed by the coordination mode and the planarity of the bis(thiosemicarbazone) ligand. In contrast, in complex 3, containing two bidentate Me2TS ligands, the Zn(II) is in a trigonal bipyramid arrangement. In all the complexes, the nitrate ion is not coordinated to the metal and acts as a counterion.

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Synthesis, structural characterisation and antibacterial activities of lead(II) and some transition metal complexes derived from quinoline-2-carboxaldehyde 4-methyl-3-thiosemicarbazone

Cited by 25 publications

References 40 publications

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

Synthesis, Spectral, Antimicrobial and In vitro Antitumorous Studies of Copper based mulltidentate thiosemicarbazones

Influence of the Reaction Conditions in the Crystal Structures of Zn(II) and Ni(II) Coordination Compounds with a Dissymmetric Bis(Thiosemicarbazone) Ligand

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