Synthesis, structural studies and antimicrobial activities of manganese, nickel and copper complexes of two new tridentate 2‑formylpyridine thiosemicarbazone ligands

Ibrahim, Ahmed B.M.; Farh, Micheal K.; El-Gyar, S. A.; El-Gahami, M. A.; Fouad, Dina M.; Silva, Francisco; Santos, Isabel C.; Paulo, António

doi:10.1016/j.inoche.2018.08.023

Cited by 37 publications

(27 citation statements)

References 40 publications

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“…The complexes exert their antimicrobial action by disintegrating the bacterial cell membrane. Recently, Ibrahim et al [133] presented nickel(II) complexes of NNS tridentate thiosemicarbazone based ligands (58, Figure 11) and evaluated them against several bacterial (e.g., E. coli, P. aeruginosa, B. cereus, S. aureus, M. luteus and S. marcescens) and fungal (e.g., F. oxysporum, C. albicans, G. candidum, A. flavus, S. brevicaulis and T. rubrum) strains. The complexes all showed similar and comparable effects as the standard antibacterial chloramphenicol drug.…”

Section: Nickel Complexesmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

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Section: Nickel Complexesmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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“…Regarding the DTC ligands, most relevantly the bands located at 1470 cm −1 and in the range of 985–966 cm −1 attributed to υ(C‐N)

{NCS}_{2}^{-}

and υ asym (C‐S) transitions, these bands in the spectra of 2 – 3 shifted to higher frequencies in agreement with the formation of the ternary complexes. Additionally, the IR spectra of these ternary complexes present broad transitions at 3450 cm −1 which indicates the presence of coordinated water molecules …”

Section: Resultsmentioning

confidence: 61%

“…In comparison to a structurally related complex with the TSC ligand {4‐(2‐chlorophenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide}, close metric parameters were investigated: For example, complex 1 conformations exhibits bond distances of (2.178(2) & 2.173(2) Å), (2.148(2) & 2.142(3) Å), (1.932(7) & 1.940(7) Å) and (1.850(7) & 1.851(7) Å) for (Ni1‐Cl1 & Ni2 Cl2), (Ni1‐S1 & Ni2‐S2), (Ni1‐N1 & Ni2‐N5) and (Ni1‐N2 & Ni2‐N6) respectively, while the corresponding bond distances are 2.1596(8), 2.1509(9), 1.928(2) and 1.847(2) Å for the reported complex …”

Section: Resultsmentioning

confidence: 99%

Nickel Complexes Bearing SNN and SS Donor Atom Ligands: Synthesis, Structural Characterization and Biological activity

Ibrahim

Farh

Santos

et al. 2019

Applied Organom Chemis

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Based on a tridentate thiosemicarbazone ligand {HL = 4‐(2,4‐dimethylphenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide}, the nickel complexes [NiCl(L)] 1, [Ni(L)(diEtdtc)(H2O)] 2 and [Ni(L)(pipdtc)(H2O)] 3 were prepared {NadiEtdtc = sodium diethyldithiocarbamate and Napipdtc = sodium piperidine dithiocarbamate} and their structures were elucidated according to their elemental analyses, solution conductivities, magnetic moments and spectroscopic (IR and electronic) data. X‐ray single crystal studies have confirmed the structure of 1 as a square planar complex in which each nickel atom is linked to three (two nitrogen and one sulfur) atoms from the thiosemicarbazone ligand and a chlorine atom to ensure the complex neutrality. Moreover, the asymmetric unit cell of the complex was found to consist of two independent complex molecules of slightly different conformations (A&B). The complexes, especially the binary one, displayed high bactericidal activities that, in several instances, were comparable to or higher than those of the chloramphenicol standard.

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“…In comparison to a structurally related complex with the TSC ligand {4‐(2‐chlorophenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide}, the most relevant metric parameters of both complexes were found almost similar: For example, complex 1 features bond distances of 2.155(2), 2.155(2), 1.953(6), and 1.857(5) Ǻ for Ni1‐Cl1, Ni1‐S1, Ni1‐N1, and Ni1‐N2, respectively, while the equivalent bond distances are 2.1596(8), 2.1509(9), 1.928(2), 1.847(2) Ǻ for the reported complex …”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural studies and antimicrobial evaluation of nickel (II) complexes of NNS tridentate thiosemicarbazone based ligands

Ibrahim

Farh

Mayer

2019

Applied Organom Chemis

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Synthesis and characterization of three nickel complexes [NiCl(L1)] 1, [NiCl(L2)] 2 and [NiCl(L3)] 3 are described {HL1 = 4‐(2,5‐dimethoxyphenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide, HL2 = 4‐(3‐nitrophenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide and HL3 = 4‐(2,4‐dimethoxyphenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide} and among the tridentate ligands HL3 is reported for the first time. The structures of the complexes were assigned based on CHNS microanalysis, spectroscopic (IR & UV–Vis.) data and solution conductivity studies. The absence of any magnetism for the complexes proved their square planar geometry. Single crystals of complex 1 were grown and analyzed by XRD analysis which confirmed the complex planarity as each Ni atom connects to three (two nitrogen and one sulfur) atoms from the thiosemicarbazone ligand and an additional chlorine atom. Packing of the complex 1 in the crystal lattice was proved to stabilize via intermolecular hydrogen bonds. Antimicrobial activities of 1–3 were studied in vitro against fungal and bacterial species and, in several instances, the complexes possessed improved antibacterial behavior in comparison to chloramphenicol.

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Synthesis, structural studies and antimicrobial activities of manganese, nickel and copper complexes of two new tridentate 2‑formylpyridine thiosemicarbazone ligands

Cited by 37 publications

References 40 publications

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Nickel Complexes Bearing SNN and SS Donor Atom Ligands: Synthesis, Structural Characterization and Biological activity

Synthesis, structural studies and antimicrobial evaluation of nickel (II) complexes of NNS tridentate thiosemicarbazone based ligands

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