Synthetic Melanotropic Peptide Initiates Erections in Men With Psychogenic Erectile Dysfunction: Double-Blind, Placebo Controlled Crossover Study

Wessells, Hunter; Fuciarelli, Kevin; Hansen, Jacob; Hadley, Mac E.; Hruby, Victor J.; Dorr, Robert T.; Levine, Norman

doi:10.1016/s0022-5347(01)62903-3

Cited by 165 publications

(126 citation statements)

References 17 publications

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“…13,15 In Study 1 men with no organic etiologies and normal nocturnal penile tumescence ( b 10 min of tip rigidity b 70%) were enrolled and designated as having psychogenic erectile dysfunction. Men with ED and major organic risk factors were enrolled in Study 2.…”

Section: Subjectsmentioning

confidence: 99%

“…12 Melanotan II, a cyclic non-selective melanocortin receptor agonist, initiates erections in rats, dogs, and humans. 13,14 We report our experience with Melanotan II in human subjects with erectile dysfunction (ED). 13,15 Materials and methods…”

Section: Introductionmentioning

confidence: 99%

“…13,14 We report our experience with Melanotan II in human subjects with erectile dysfunction (ED). 13,15 Materials and methods…”

Section: Introductionmentioning

confidence: 99%

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Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II

et al. 2000

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We review our experience with Melanotan II, a non-selective melanocortin receptor agonist, in human subjects with erectile dysfunction (ED). Melanotan II was administered to 20 men with psychogenic and organic ED using a double-blind placebo-controlled crossover design. Penile rigidity was monitored for 6 h using RigiScan. Level of sexual desire and side effects were reported with a questionnaire.In the absence of sexual stimulation, Melanotan II led to penile erection in 17 of 20 men. Subjects experienced a mean of 41 min Rigiscan tip rigidity b 80%. Increased sexual desire was reported after 13a19 (68%) doses of Melanotan II vs 4a21 (19%) of placebo (P`0.01). Nausea and yawning were frequently reported side effects due to Melanotan II; at a dose of 0.025 mgakg, 12.9% of subjects had severe nausea.We conclude that Melanotan II is a potent initiator of penile erection in men with erectile dysfunction. Our ®ndings warrant further investigation of melanocortin agonists and antagonists on penile erection.

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Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II

et al. 2000

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“…L'apomorphine, agoniste dopaminergique ~ effet central, rejoint les traitements de premiere intention comme d'autres produits pro~rectiles d~livr~s par voie orale, le vacuum et la psychoth~rapie [132]. En tant que produit ~ effet central, l'apomorphine peut ~tre compar~ au melanotan II, agoniste des r~cepteurs de la m~lanocortine [135]. En tant que produit d61ivr6 per os, l'apomorphine rejoint les inhibiteurs des phosphodiest6rases [56] et les antagonistes des r6cepteurs alpha-adr6nergiques [55].…”

Section: Discussionunclassified

Apomorphine, systèmes dopaminergiques centraux et contrôle de l’érection

Rampin

2002

Androl.

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Au cours des dernieres ann~es, les nombreuses donnees fondamentales ~lucidant les mecanismes Iocaux de I'~rection ont permis de proposer des traitements des dysfonctions ~rectiles par des m~dicaments a action p~ripherique. Ces produits permettent soit de provoquer une erection, ils sont alors efficaces seuls, soit de potentialiser une ~rec-tion.Dans un environnement sexuellement stimulant, I'~rection est provoquee par une modification de I'equilibre des effets antierectiles du syst~me sympathique et des effets pro~rectiles du syst~me parasympathique. Les voies sympathiques et parasympathiques naissent de la moelle ~pini~re. Le syst~-me nerveux central agit sur la moelle (~pini~re pour contr61er et modifier cet equilibre sympathiqueparasympathique. La dopamine est un neurom~dia-teur du syst~me nerveux central agissant sur le comportement sexuel et sur les noyaux centaux contr61ant le tractus g~nital chez le m&le. Les taux de dopamine augmentent dans plusieurs noyaux centraux (amygdale, aire preoptique mediane) pendant I'activit~ sexuelle chez le rat. Les agonistes dopaminergiques a action centrale comme I'apomorphine (agoniste DI/D2) provoquent I'~rection chez I'homme, le singe et le rat. Chez le rat, les effets proerectiles de I'apomorphine sont dus ~ sa fixation sur des recepteurs de type D2 dans le noyau paraventriculaire de I'hypothalamus (PVN), et seraient regul(~s par la testosterone. Des investigations cliniques r~centes ont mis en avant les avantages de I'utilisation de I'apomorphine pour traiter les patients souffrant de dysfonctions ~rec-tiles. Une molecule a action centrale comme I'apomorphine pourrait r~organiser I'~quilibre sympathique-parasympathique, conduisant & un recrutement adapte des voies nerveuses vers le p~nis. Mots-cl#,s : apomorphine, dopamine, erection, ejaculation, dysfonction 6rectile, c o m p o r t e m e n t sexuel.

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“…A administração de agonistas do MC4R aumenta a função erétil peniana e a atividade sexual em camundongos (65). A droga "Melanotan-II", um análogo do α-MSH com atividade agonista para os receptores MC1R, MC3R, MC4R e MC5R, estimula a ereção peniana e o desejo sexual em homens (66,67). Não se sabe qual MCR é responsável pelo efeito pró-erétil da droga.…”

Section: Controle Neuroendócrino Do Pesounclassified

Controle neuroendócrino do peso corporal: implicações na gênese da obesidade

Rodrigues

Suplicy

Radominski

2003

Arq Bras Endocrinol Metab

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Arq Bras Endocrinol Metab vol 47 nº 4 Agosto 2003 398 RESUMOO peso corporal é regulado por uma interação complexa entre hormônios e neuropeptídeos, sob o controle principal de núcleos hipotalâmicos. Mutações nos genes de hormônios e neuropeptídeos, de seus receptores ou de elementos regulatórios, têm sido descritas na espécie humana, mas são tidas como raras, não explicando as formas mais comuns de obesidade. No entanto, o estudo destas mutações tem propiciado um grande avanço nos conhecimentos sobre a base genéti-ca e a fisiopatologia da obesidade, possibilitando o estudo e abrindo perspectivas para o desenvolvimento de novas modalidades terapêuti-cas. Recentemente, demonstrou-se que mutações no receptor 4 da melanocortina podiam ser encontradas em até 5% dos casos de obesidade severa, representando até o presente momento a forma mais prevalente de obesidade monogênica na espécie humana. Nesta revisão, são discutidas as diversas mutações descritas nos seres humanos de elementos da rede neuroendócrina de controle do peso corporal, bem como as implicações dos mesmos na gênese da obesidade. A complex hypothalamic network of hormones and neuropeptides regulates body weight. Mutations in these hormones/peptides, their receptors or regulatory elements, have been described in humans, but they are rare and could not explain the commonest forms of obesity. Nevertheless, the study of these mutations has favored a great progress in the knowledge of genetic basis and physiopathology of obesity, opening new perspectives on the therapeutic approach of this prevalent disease. Recently, mutations in the melanocortin 4 receptor have been found in up to 5% of severe obese subjects, being thus far the most prevalent monogenic form of obesity in humans. In this revision, we discuss the mutations described in some elements of the body weight regulation system in humans, and their implications for the genesis of obesity. no aumento global da prevalência da obesidade, há muitas evidências de que a genética contribui substancialmente para a regulação do peso corporal. Estudos de correlação do índice de massa corporal (IMC) em gêmeos monozigóticos, gêmeos dizigóticos, irmãos biológicos e adotivos sugerem que a herança da obesidade é de 50-90% (1). Acredita-se que a revisão Controle Neuroendócrino do Peso Corporal: Implicações na Gênese da Obesidade

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Synthetic Melanotropic Peptide Initiates Erections in Men With Psychogenic Erectile Dysfunction: Double-Blind, Placebo Controlled Crossover Study

Abstract: Melanotan-II is a potent initiator of erections in men with psychogenic erectile dysfunction and has manageable side effects at a dose of 0.025 mg./kg.

Cited by 165 publications

References 17 publications

Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II

Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II

Apomorphine, systèmes dopaminergiques centraux et contrôle de l’érection

Controle neuroendócrino do peso corporal: implicações na gênese da obesidade

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