2020
DOI: 10.3389/fmicb.2020.02053
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Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-Resistant Candida albicans in Hyphal, Biofilm, and Intracellular Forms: An Application for Skin-Infection Treatment

Abstract: Candida albicans is the most common cause of fungal infection. The emergence of drug resistance leads to the need for novel antifungal agents. We aimed to design naphthofuranquinone analogs to treat drug-resistant C. albicans for topical application on cutaneous candidiasis. The time-killing response, agar diffusion, and live/dead assay of the antifungal activity were estimated against 5-fluorocytosine (5-FC)-or fluconazoleresistant strains. A total of 14 naphthofuranquinones were compared for their antifungal… Show more

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Cited by 9 publications
(7 citation statements)
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“…The in vivo efficacy of antifungals was examined using a mouse subcutaneous C. albicans infection model. , Immunosuppressed mice (KM, male) were infected by subcutaneous injection of 100 μL 1× 10 9 CFU/mL C. albicans on the back.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The in vivo efficacy of antifungals was examined using a mouse subcutaneous C. albicans infection model. , Immunosuppressed mice (KM, male) were infected by subcutaneous injection of 100 μL 1× 10 9 CFU/mL C. albicans on the back.…”
Section: Resultsmentioning
confidence: 99%
“…The subcutaneous Candida infection model was conducted by a method similar to a reported protocol. 45 Mice were continuously intraperitoneally injected (i.p.) with cyclophosphamide (100 mg/kg on the first and third days, 150 mg/kg on the second day) to obtain an immunosuppressive mice model.…”
Section: Detection Of Inflammatory Factors (Il-6 and Tnf-α)mentioning
confidence: 99%
“…Both blastoconidia and hyphae play a crucial role in pathogenesis; however, these display different functions, which include adhesion and invasion [ 82 ]. Several studies have focused on inhibiting these morphological transitions in pathogenic fungi; nevertheless, there is scarce knowledge about the action of natural compounds against this virulence trait in C. albicans [ 83 , 84 , 85 , 86 , 87 , 88 , 89 ]. Some natural and synthetic compounds have been tested and found to be effective in affecting germ tubes or pseudo-hyphae in C. albicans [ 77 , 80 , 84 , 85 ].…”
Section: Discussionmentioning
confidence: 99%
“…The first method is the classical method of directly applying CA solution to the exfoliated epidermis, described by Gaspari ( Santus et al, 2018 ). In this study, we selected the second method of direct intradermal injection discovered by Fang ( Fang et al, 2020 ) to induce the formation of a CA infection model. Five days after inoculation, white membranes, necrosis, erosions, and ulcers appeared on the back of mice.…”
Section: Discussionmentioning
confidence: 99%