Synthetic studies on CP-225,917 and CP-263,114: concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reactionElectronic supplementary information (ESI) available: crystal data for 13a. See http://www.rsc.org/suppdata/p1/b2/b202752f/

Design, Synthesis and Bioactivity of [3.3.3]Propellane-Based Voltage-Gated Calcium Channel α2δ Subunit Ligands

“…单 缩 酮 10 通 过 Wolff-Kishner-黄鸣龙还原得到缩酮 11, 后者在 p-TsOH 催化下在含水丙酮中室温下水解得到螺桨烷单酮 12. 12 在 TiCl 4 /吡啶催化下与丙二酸二甲酯发生 Knoevenagel 缩合反应, 得到 Michael 加成的受体 13 [16] . 在 K 2 CO 3 催 化下, 化合物 13 与三甲基氰硅烷(TMSCN)在甲醇中发 生 Michael 加成反应 [17] [19] 、苄基 氯化镁(路线四) [20] 和对甲氧基氯化镁(路线五) [21] .…”

The Art of Innovation in Organic Chemistry: Synthetic Efforts toward the Phomoidrides

“…Alan Armstrong and Colleagues. Alan Armstrong and co-workers at the University of Nottingham in England have studied a Mukaiyama aldol reaction to construct the bicyclic phomoidride ring system. − As shown in Scheme 37, they began by treating the lithium enolate of cyclohexanone with diethyl oxomalonate to give aldol product 200 . A two-step elimination/isomerization sequence was used to install the requisite enone 201 , which was alkylated with bromide 202 .…”