System Markers of Acute Pancreatitis Severity at the Aseptic Phase
Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Cited by 2 publications
References 0 publications
Dishomeostatic phenomena in acute pancreatitis of variable severity
Acute pancreatitis remains one of the most dangerous pathologies in the structure of emergency abdominal surgery. This is due to many reasons, including an increase in the frequency of destructive forms of the disease, high mortality, and frequent unfavorable outcomes. The aim of this study was to investigate a number of leading components of homeostasis in patients with acute pancreatitis of varying severity. A retrospective study was conducted on 50 patients with acute pancreatitis of diff erent severity levels who were hospitalized at the Republican Clinical Hospital named after S.V. Katkovа (Saransk, Russia). The patients were divided into groups: the fi rst group (control, n = 30) consisted of patients with mild acute pancreatitis, and the second group (main, n = 20) consisted of patients with severe acute pancreatitis. The study evaluated the endogenous intoxication syndrome, the activity of lipid peroxidation and phospholipase systems, microcirculation status, liver function, and the activity of the coagulation-lytic blood system. The results showed that in the early stages of acute pancreatitis, several pathological processes were observed: the development of endotoxemia syndrome, activation of lipid peroxidation and phospholipase systems, microcirculation disorders, changes in the coagulation and fibrinolytic links of the hemostasis system, and liver function suppression. The severity of these disorders was associated with the severity of the pathology. In cases of mild severity, the changes in the parameters studied were reversible, while in severe cases they were stable and oftenirreversible. The presence of toxemia, oxidative stress, dysmicrocirculation, and hemostatic disorders should be considered as risk factors for disease progression and complications.
Dishomeostatic phenomena in acute pancreatitis of variable severity
Acute pancreatitis remains one of the most dangerous pathologies in the structure of emergency abdominal surgery. This is due to many reasons, including an increase in the frequency of destructive forms of the disease, high mortality, and frequent unfavorable outcomes. The aim of this study was to investigate a number of leading components of homeostasis in patients with acute pancreatitis of varying severity. A retrospective study was conducted on 50 patients with acute pancreatitis of diff erent severity levels who were hospitalized at the Republican Clinical Hospital named after S.V. Katkovа (Saransk, Russia). The patients were divided into groups: the fi rst group (control, n = 30) consisted of patients with mild acute pancreatitis, and the second group (main, n = 20) consisted of patients with severe acute pancreatitis. The study evaluated the endogenous intoxication syndrome, the activity of lipid peroxidation and phospholipase systems, microcirculation status, liver function, and the activity of the coagulation-lytic blood system. The results showed that in the early stages of acute pancreatitis, several pathological processes were observed: the development of endotoxemia syndrome, activation of lipid peroxidation and phospholipase systems, microcirculation disorders, changes in the coagulation and fibrinolytic links of the hemostasis system, and liver function suppression. The severity of these disorders was associated with the severity of the pathology. In cases of mild severity, the changes in the parameters studied were reversible, while in severe cases they were stable and oftenirreversible. The presence of toxemia, oxidative stress, dysmicrocirculation, and hemostatic disorders should be considered as risk factors for disease progression and complications.
Thromboelastography in Express Estimation of Hemostatic System in Patients With Acute Pancreatitis
The problem of diagnostics and treatment of acute pancreatitis (AP) is relevant for emergency surgery. Both clinicians and specialists in paraclinical disciplines thoroughly examine pathogenesis of this serious disease, as their observations will contribute greatly to targeted therapy. The problem of hemostatic disorders still remains one of the poorly studied. The aim of the work is to assess the hemostatic system in patients with acute pancreatitis of various severity upon admission to the clinic. Materials and Methods. The authors examined 48 patients with acute pancreatitis, who were divided into two groups: group 1 (control, n=24) consisted of patients with mild AP; Group 2 (comparison, n=24) included patients with severe AP. Moreover, healthy individuals were also examined during the trial (norm, n=14). Disease severity is determined according to APACHE II Scoring System and national clinical guidelines. Blood coagulation-lytic system was evaluated by a number of biochemical tests (APTT, IPT, and fibrinogen) and according to some thromboelastography parameters (reaction time, coagulation time, α-angle and maximum amplitude) (TEG® 5000 Thrombelastograph®, USA). Results. It was found out that on admission thromboelastography allows clinicians to get an integrated picture of the blood coagulation system in the shortest possible time and on a full scale. These data significantly supplement the information on the coagulation-lytic system obtained by the biochemical method. It turned out that on admission patients with acute pancreatitis demonstrated significant disorders of the hemostatic system humoral component, such as hypercoagulemia and fibrinolytic inhibition. It is shown that disorders of the hemostatic system are associated with the severity of pathology. Conclusions. The information obtained can serve as the key element for targeted timely vector therapy in correction (prevention) of hemostatic derangements, the most important link in microcirculatory disorders. Keywords: hemostasis, coagulation, acute pancreatitis, thromboelastography. Проблема диагностики и лечения острого панкреатита (ОП) остается актуальной для неотложной хирургии. Усилия клиницистов и специалистов параклинических дисциплин направлены на углубленное изучение патогенеза этой тяжелой болезни, результаты которого обеспечат проведение целенаправленной терапии. Одним из малоизученных является вопрос гемостатических нарушений. Целью работы явилась оценка состояния системы гемостаза у больных ОП различной тяжести при поступлении в клинику. Материалы и методы. Проведено исследование 48 пациентов с острым панкреатитом, разделенных на группы: І группа (контроль, n=24) – пациенты с ОП легкой формы; ІІ группа (сравнение, n=24) – пациенты с ОП тяжелой степени. Для сравнения были обследованы здоровые лица (норма, n=14). Степень тяжести заболевания определена с помощью шкалы АРАСНЕ-ІІ и в соответствии с национальными клиническими рекомендациями. Состояние коагуляционно-литической системы крови оценено по ряду биохимических тестов (АЧТВ, ПТИ и фибриноген) и при помощи некоторых параметров (реакционное время, время коагуляции, величина α-угла и максимальная амплитуда) тромбоэластографии (TEG® 5000 Thrombelastograph®, USA). Результаты. Выявлено, что проведение тромбоэластографии при госпитализации позволяет получить интегральную картину состояния свертывающей системы крови в кратчайший срок и в полном объеме. Эти данные существенно дополняют сведения о состоянии коагуляционно-литической системы, полученные биохимическим путем. Оказалось, что при поступлении в клинику у больных ОП регистрируются значительные расстройства гуморального компонента системы гемостаза в виде гиперкоагулемии и угнетения фибринолиза. Показано, что расстройства в системе гемостаза сопряжены с тяжестью патологии. Выводы. Полученные сведения могут служить основой для целенаправленной своевременной векторной терапии при коррекции (предупреждении прогрессирования) гемостатических расстройств – важнейшего звена нарушения микроциркуляции. Ключевые слова: гемостаз, коагуляция, острый панкреатит, тромбоэластография.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
Contact Info
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Product
Resources
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.
