Systematic review and meta-analysis of the effects of statin therapy on abdominal aortic aneurysms

Twine, Christopher P.; Williams, Ian

doi:10.1002/bjs.7343

Cited by 98 publications

(63 citation statements)

References 38 publications

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“…The findings reported here for lipid-lowering drugs are consistent with other meta-analyses showing a possible association between statin usage and slower aneurysm growth rate. 18,19,98 The finding that ACE inhibitors increased growth rates in the UKSAT 79 was not substantiated by other studies. Particularly in the older studies, few of the patients included in the current meta-analysis were taking cardioprotective medications and even if patients were taking these drugs at baseline, there is no evidence about continued patient compliance with medication.…”

Section: Discussionmentioning

confidence: 91%

Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

Thompson

Brown²,

Sweeting³

et al. 2013

Health Technology Assessment

186

177

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This report should be referenced as follows:Thompson SG, Brown LC, Sweeting MJ, Bown MJ, Kim LG, Glover MJ, et al. Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technol Assess 2013;17(41). Health Technology Assessment is indexed in MEDLINE, CINAHL, EMBASE, The Cochrane Library and the ISI Science Citation Index and is assessed for inclusion in the Database of Abstracts of Reviews of Effects. Health Technology Assessment is indexed and abstracted inThis journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: www.hta.ac.uk/ This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 08/30/02. The contractual start date was in November 2009. The draft report began editorial review in July 2012 and was accepted for publication in November 2012. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research...

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Section: Discussionmentioning

confidence: 91%

Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

Thompson

Brown²,

Sweeting³

et al. 2013

Health Technology Assessment

186

177

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show abstract

“…Statins should be prescribed as they decrease all---cause mortality and cardiovascular mortality after surgery for AAA (Kertai et al 2004) and also reduce the risk of cardiac morbidity and mortality by half, within 30 days of surgery (Schouten et al 2009). Previously it has been thought that statins would reduce growth---rate of AAA (Schouten et al 2006, Schlösser et al 2008, but a more recent and larger study indicates that this is not the fact (Ferguson et al 2010), and the same conclusion is drawn in a meta---analysis (Twine, Williams 2011).…”

Section: Surveillance and Treatment Other Than Surgicalmentioning

confidence: 68%

Abdominal Aortic Aneurysm : Aspects on how to affect mortality from rupture

Hager¹

2014

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“…Due to current investigation of markers associated with AAA, targeted ultrasound imaging may be a future option (Moxon et al, 2010;Villanueva 2008). With increased knowledge of pathophysiological mechanisms, pharmacotherapy or gene therapy may be available for stabilization of aneurysms (Baxter et al, 2008;Cooper et al, 2009;Golledge et al, 2009;Raffetto & Khalil, 2008;Twine & Williams, 2011). It may then be interesting to apply drug-or gene-loaded contrast agents, which could be monitored and destructed using ultrasound for local drug delivery.…”

Section: Functional and Molecular Imagingmentioning

confidence: 99%

Ultrasound in Abdominal Aortic Aneurysm

Brekken¹,

Dahl²,

Hernes³

2011

Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms

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Systematic review and meta-analysis of the effects of statin therapy on abdominal aortic aneurysms

Abstract: The claim of a reduction in AAA expansion rate with statin therapy is based on low-quality evidence and was not significant on meta-analysis. However, statin therapy did appear to improve all-cause survival after AAA repair.

Cited by 98 publications

References 38 publications

Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

Abdominal Aortic Aneurysm : Aspects on how to affect mortality from rupture

Ultrasound in Abdominal Aortic Aneurysm

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