Systematic review: The oncological safety of adipose fat transfer after breast cancer surgery

Waked, Karl; Colle, Julien; Doornaert, Maarten; Cocquyt, Véronique; Blondeel, Phillip

doi:10.1016/j.breast.2016.11.001

Cited by 66 publications

(41 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another concern is the use of cell therapy in areas with previous malignancy, as preclinical data have suggested that cell therapy can aggravate any remaining cancer cells . However, this has so far not been shown in the clinical setting, as we only could identify one case of recurrence following cell‐assisted lipotransfer among 121 breast cancer patients, which is well within what could be expected . It is vital in the setting of previous cancer treatment that safety evaluations are conducted thoroughly with sufficiently long follow‐up times, so these initial uplifting results can be confirmed.…”

Section: Discussionmentioning

confidence: 77%

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Toyserkani

Jørgensen

Tabatabaeifar

et al. 2017

Stem Cells Translational Medicine

110

View full text Add to dashboard Cite

The popularity of adipose‐derived cell therapy has increased over the last decade, and the number of studies published annually is growing. However, concerns regarding safety in the setting of previous malignancy or the use of allogeneic cells have been raised. We therefore aimed to systematically review all clinical studies using adipose‐derived cell therapy to identify reported adverse events with a special focus on risk of thromboembolic, immunological, and oncological safety concerns. Our systematic search resulted in 70 included studies involving more than 1,400 patients that were treated with adipose‐derived cell therapy. Safety assessment method was not described in 32 of the included studies. For studies involving systemic or cardiac administration, one case of pulmonary thromboembolism and cases of both myocardial and cerebral infarctions were described. In the setting of allogeneic cell therapy studies, where the production of specific antibodies toward donor cells was examined, it was noted that 19%–34% of patients develop antibodies, but the consequence of this is unknown. With regard to oncological safety, only one case of breast cancer recurrence was identified out of 121 patients. Adipose‐derived cell therapy has so far shown a favorable safety profile, but safety assessment description has, in general, been of poor quality, and only adverse events that are looked for will be found. We encourage future studies to maintain a strong focus on the safety profile of cell therapy, so its safeness can be confirmed. stem cells translational medicine 2017;6:1786–1794

show abstract

Section: Discussionmentioning

confidence: 77%

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Toyserkani

Jørgensen

Tabatabaeifar

et al. 2017

Stem Cells Translational Medicine

110

View full text Add to dashboard Cite

show abstract

“…Data were analyzed using SPSS version 22.0 (IBM statistics for Windows version 22, IBM Corporation, Armonk, NY, USA). [13][14][15][16][17][18][19], and replacement with the final prosthesis was performed after a mean of 19 weeks (range 17-25). The mean volume of the definitive prosthesis was 438 cc (range 150-800 cc): although there were no statistically significant differences between groups (p > 0.05), larger volume prostheses were used in group 1 (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Even in breast implant augmentation, lipofilling now has a well-recognized role [10,11]. A large number of studies have investigated the technique of fat grafting, its safety in breast surgery, the variations offered by the different types of harvesting techniques, optimal donor site, device employed, elaboration of adipose tissue, recipient site preparation, and timing of surgery [12][13][14][15][16][17][18][19][20]. Many reviews are available comparing dozens of studies, analyzing every step of the lipofilling procedure, in order to find a standard method to ensure the best graft-taking rate [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Long-term impact of lipofilling in hybrid breast reconstruction: retrospective analysis of two cohorts

et al. 2019

View full text Add to dashboard Cite

Lipofilling has recently gained popularity as a tool in primary treatment of breast cancer, and its association with two-stage implant breast reconstruction is considered as standard treatment in many centers. However, no data are available about the longterm results of the association of lipofilling in combination with expander-implant reconstruction. A retrospective analysis was conducted on patients treated between January 2010 and December 2014. Two groups were compared. Group 1 had a standard expander-implant two-stage reconstruction. Group 2 underwent hybrid breast reconstruction (HBR). Patient characteristics, hospitalization, outcomes, reoperation details, outpatient visits, and evaluation questionnaires were taken into consideration. Intergroup comparison was performed using Wilcoxon Mann-Whitney U test and Pearson's chi-square test or Fisher's exact test for categorical variables. Two hundred fourteen patients were evaluated: 130 patients in group 1 and 84 patients in group 2. Group 2 showed significant benefits over group 1 in terms of capsular contracture rate, breast pain, and displacement/rotation of the implant (p = 0.005). The HBR protocol is associated with lower rate of capsular contracture, less breast pain at long follow-up times, and lower overall rates of revision surgery compared to standard expander-implant reconstruction. A specific cost analysis will help further clarify the advantages of this protocol over a standard procedure. Level of Evidence: Level III, risk/prognostic, therapeutic study.

show abstract

“…Several metaanalyses and systematic reviews have unanimously concluded that autologous fat transfer does not lead to an increased rate of locoregional breast cancer recurrence. [65][66][67][68][69][70] However, as mentioned previously, a higher rate of biopsies exists with patients who have undergone fat grafting to the breasts compared with the general population, as fat necrosis may be difficult to distinguish radiographically from breast cancer. 21,22 That is, to date there is a substantial amount of evidence that fat grafting remains a safe and highly effective option for cosmetic breast surgery in patients with a history of breast cancer.…”

Section: Oncological Safetymentioning

confidence: 99%

Application of Fat Grafting in Cosmetic Breast Surgery

Davis

Perdanasari

Abu‐Ghname

et al. 2020

Seminars in Plastic Surgery

View full text Add to dashboard Cite

The role of fat grafting to the breasts has evolved in the recent past, gaining several new applications within both reconstructive and aesthetic surgery. Initially used for reconstructive purposes to fill lumpectomy defects or to correct residual contour deformities after breast reconstruction, it has since made its way into cosmetic breast surgery and has grown to encompass a wide variety of new indications. Fat grafting in aesthetic breast surgery may be performed as a form of primary autologous breast augmentation or as an adjunct to implant-based breast augmentation to disguise implant edges. It may also be used to provide added volume after explant surgery or to provide improvements in breast contour alongside mastopexy techniques. In this article, we will review the current applications of fat grafting in aesthetic breast surgery and provide an up-to-date summary of its reported outcomes, safety, and complications.

show abstract

Systematic review: The oncological safety of adipose fat transfer after breast cancer surgery

Cited by 66 publications

References 98 publications

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Long-term impact of lipofilling in hybrid breast reconstruction: retrospective analysis of two cohorts

Application of Fat Grafting in Cosmetic Breast Surgery

Contact Info

Product

Resources

About